Exercise Dose Dependent Atrial Remodelling and Atrial Fibrillation

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dc.contributor.advisorBackx, Peter
dc.contributor.authorYakobov, Simona
dc.date.accessioned2020-11-13T13:56:51Z
dc.date.available2020-11-13T13:56:51Z
dc.date.copyright2020-09
dc.date.issued2020-11-13
dc.date.updated2020-11-13T13:56:51Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe dependence of atrial fibrillation (AF) on exercise dose is U shaped. To assess the physiological basis for this relationship, we swam 3 groups of CD1 mice at variable daily durations (120, 180 and 240 minutes per day) while ensuring that all mice received similar amounts of total exercise. To do this, we measured O2 consumption rates during swims and quantified exercise effort using volumes of O2 consumed during swimming. Consistent with comparable total exercise effort, all 3 groups showed similar reductions in body weight and similar changes in most ventricular parameters, despite a trend towards lower heart rates with increased swim durations. AF vulnerability, atrial fibrosis, atrial hypertrophy, and P-wave duration were associated with exercise dose, and we suggest that increases in atrial pressure that occur with longer exercise durations promote this remodelling. Collectively, our data demonstrate that AF vulnerability and adverse atrial changes rise as exercise duration increases.
dc.identifier.urihttp://hdl.handle.net/10315/37959
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectAnimal diseases
dc.subject.keywordsAtrial fibrillation
dc.subject.keywordsAtrial remodelling
dc.subject.keywordsAtria
dc.subject.keywordsVentricles
dc.subject.keywordsFibrosis
dc.subject.keywordsCardiovascular disease
dc.subject.keywordsU shape
dc.subject.keywordsDose dependence
dc.subject.keywordsOxygen consumption
dc.subject.keywordsExercise dose
dc.subject.keywordsExercise volume
dc.subject.keywordsExercise intensity
dc.subject.keywordsExercise duration
dc.subject.keywordsExercise
dc.subject.keywordsEndurance sport
dc.subject.keywordsSwimming
dc.subject.keywordsMice
dc.subject.keywordsCD1 mice
dc.subject.keywordsLeft ventricular end diastolic pressure
dc.subject.keywordsPressure load
dc.subject.keywordsAtrial stretch
dc.subject.keywordsAtrial hypertrophy
dc.subject.keywordsCollagen
dc.subject.keywordsReentry
dc.subject.keywordsInducibility
dc.subject.keywordsSusceptability
dc.subject.keywordsAF
dc.subject.keywordsExercise quantification
dc.subject.keywordsRemodelling
dc.subject.keywordsSinus bradycardia
dc.subject.keywordsParasympathetic
dc.subject.keywordsVagal tone
dc.subject.keywordsP wave duration
dc.subject.keywordsHeart rate
dc.subject.keywordsAtropine
dc.subject.keywordsPhysical activity
dc.subject.keywordsCardiorespiratory fitness
dc.titleExercise Dose Dependent Atrial Remodelling and Atrial Fibrillation
dc.typeElectronic Thesis or Dissertation

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