YorkSpace has migrated to a new version of its software. Access our Help Resources to learn how to use the refreshed site. Contact diginit@yorku.ca if you have any questions about the migration.
 

The Role of PGC-1 alpha in Mediating Exercise-Induced TFEB Expression and Activity in Skeletal Muscle

Simple item page
dc.contributor.advisorHood, David A.
dc.creatorErlich, Avigail Tamar
dc.date.accessioned2017-07-27T12:43:34Z
dc.date.available2017-07-27T12:43:34Z
dc.date.copyright2016-12-08
dc.date.issued2017-07-27
dc.date.updated2017-07-27T12:43:34Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractA healthy mitochondrial pool in skeletal muscle is maintained by the coordinated processes of biogenesis and mitophagy. PGC-1alpha is a key transcriptional co-activator necessary for mitochondrial synthesis, whereas transcription factor EB (TFEB) regulates the degradation of dysfunctional organelles via activation of genes associated with autophagy. Despite TFEB's known role as a key regulator of autophagy and lysosomal genes, its response to exercise and the mechanisms behind its transcription and activation have yet to be elucidated. To identify TFEB's role and its dependence on PGC-1alpha, we subjected WT and PGC-1alpha KO mice to an acute bout of exercise and analyzed factors regulating TFEB transcription and nuclear translocation. We found a PGC-1alpha-dependent induction of TFEB transcription and activation with exercise, proving a strong correlation between the two processes involved in mitochondrial quality control.
dc.identifier.urihttp://hdl.handle.net/10315/33474
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subject.keywordsMuscle
dc.subject.keywordsMitochondria
dc.subject.keywordsMitochondrial biogenesis
dc.subject.keywordsAutophagy
dc.subject.keywordsMitophagy
dc.subject.keywordsTFEB
dc.subject.keywordsLysosomes
dc.subject.keywordsPGC-1alpha
dc.subject.keywordsExercise
dc.titleThe Role of PGC-1 alpha in Mediating Exercise-Induced TFEB Expression and Activity in Skeletal Muscle
dc.typeElectronic Thesis or Dissertation

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Erlich_Avigail_T_2016_Masters.pdf
Size:
18.2 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.83 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
YorkU_ETDlicense.txt
Size:
3.38 KB
Format:
Plain Text
Description:
Download

Collections

Kinesiology & Health Science

All items in the YorkSpace institutional repository are protected by copyright, with all rights reserved except where explicitly noted.