Regulation of Thermogenic Capacity in White and Brown Adipose Tissues by Chronic Endurance Exercise and High-Fat Diet

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dc.contributor.advisorCeddia, Rolando
dc.creatorWu, Michelle Victoria
dc.date.accessioned2015-12-16T19:27:07Z
dc.date.available2015-12-16T19:27:07Z
dc.date.copyright2015-08-20
dc.date.issued2015-12-16
dc.date.updated2015-12-16T19:27:07Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThis study investigated the effects of high-fat (HF) diet and chronic endurance exercise (Ex) on the regulation of thermogenic capacity in both brown adipose tissue (BAT) and subcutaneous (SC) white adipose tissue (WAT), and how it affects whole-body energy expenditure (EE). Analysis of tissue mass, PGC-1α and UCP-1 content, presence of multilocular adipocytes and palmitate oxidation revealed that HF diet increased the thermogenic capacity of BAT, while Ex suppressed it. Conversely, Ex induced the browning of the SC WAT, indicated by an increased number of multilocular adipocytes, as well as PGC-1α and UCP-1 content, and palmitate oxidation, whereas HF diet attenuated this effect. Despite reducing thermogenic capacity of BAT, Ex increased whole-body EE during the dark cycle. We propose that exercise-induced browning of SC WAT reduces thermogenic capacity in core body regions to manage the increased heat production of exercise, and increases it in peripheral regions to adjust metabolic rate.
dc.identifier.urihttp://hdl.handle.net/10315/30720
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subjectPhysiology
dc.subjectBiology
dc.subject.keywordsbrown adipose tissue
dc.subject.keywordsadipose tissue
dc.subject.keywordsmetabolism
dc.subject.keywordsfat
dc.subject.keywordspgc-1a
dc.subject.keywordsATGL
dc.subject.keywordslipolysis
dc.subject.keywordsthermogenesis
dc.subject.keywordsUCP-1
dc.subject.keywordsp-AMPK
dc.subject.keywordswhite adipose tissue
dc.subject.keywordsbeige fat
dc.subject.keywordsthermogenic capacity
dc.subject.keywordsplasticity
dc.subject.keywordsuncoupling
dc.subject.keywordsFNDC5
dc.subject.keywordsirisin
dc.subject.keywordsmuscle
dc.subject.keywordspalmitate oxidation
dc.titleRegulation of Thermogenic Capacity in White and Brown Adipose Tissues by Chronic Endurance Exercise and High-Fat Diet
dc.typeElectronic Thesis or Dissertation

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