The Role of TFE3 in Mediating Skeletal Muscle Mitochondrial Adaptations to Exercise Training

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dc.contributor.advisorHood, David A.
dc.contributor.authorWong, Jenna Caitlin
dc.date.accessioned2023-08-04T15:21:02Z
dc.date.available2023-08-04T15:21:02Z
dc.date.issued2023-08-04
dc.date.updated2023-08-04T15:21:02Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractMaintenance of a healthy mitochondrial pool is essential for skeletal muscle function. Mitophagy, the selective clearance of dysfunctional mitochondria, optimizes the mitochondrial network and heavily relies on lysosomal capacity within the tissue. The transcription factor E3 (TFE3) is a protein that activates the expression of lysosomal genes. With exercise, TFE3 is presumed to optimize the mitochondrial pool through the removal of organelles via lysosomes. However, the molecular mechanisms of the involved pathways remain unknown. Using WT and whole-body TFE3 KO mice, we sought to determine the role of TFE3 in regulating basal skeletal muscle mitochondrial function in response to acute and chronic endurance exercise. Our results suggest that the loss of TFE3 compromises beneficial training adaptations leading to improved muscle endurance and mitochondrial function and may induce a greater sensitivity to mitophagy induction in untrained muscle.
dc.identifier.urihttps://hdl.handle.net/10315/41389
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subjectPhysiology
dc.subjectMolecular biology
dc.subject.keywordsTranscription factor E3
dc.subject.keywordsTFE3
dc.subject.keywordsExercise
dc.subject.keywordsEndurance training
dc.subject.keywordsSkeletal muscle
dc.subject.keywordsMitochondria
dc.subject.keywordsMitophagy
dc.subject.keywordsAutophagy
dc.subject.keywordsLysosome
dc.titleThe Role of TFE3 in Mediating Skeletal Muscle Mitochondrial Adaptations to Exercise Training
dc.typeElectronic Thesis or Dissertation

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