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Prenatal Fluoride Exposure and Neurodevelopmental Outcomes in a National Birth Cohort

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dc.contributor.advisorTill, Christine
dc.creatorGreen, Rivka Ruth
dc.date.accessioned2018-11-21T13:44:12Z
dc.date.available2018-11-21T13:44:12Z
dc.date.copyright2018-07-05
dc.date.issued2018-11-21
dc.date.updated2018-11-21T13:44:12Z
dc.degree.disciplinePsychology(Functional Area: Clinical-Developmental)
dc.degree.levelMaster's
dc.degree.nameMA - Master of Arts
dc.description.abstractBackground: The potential neurotoxicity of exposure to fluoride, which has sparked controversy about community water fluoridation, is poorly understood. Objective: To test the association between prenatal fluoride exposure and childhood IQ in 512 Canadian mother-child pairs. Methods: We measured fetal exposure to fluoride using: (a) maternal urinary fluoride (MUF) during pregnancy; (b) fluoride concentration in water; and (c) fluoride intake estimated from beverage consumption. We evaluated childrens IQ using the Wechsler Primary and Preschool Scale of Intelligence-III. Multiple linear regression analyses examined covariate-adjusted associations between fluoride predictors and IQ. Results: Higher MUF levels predicted lower IQ in males (B=-4.49, p=.02) but not females. Higher levels of water fluoride and fluoride intake predicted a main effect of diminished IQ. Conclusion: Exposure to fluoride during fetal development is associated with lower IQ scores. These findings, which suggest that fluoride is neurotoxic, underscore the need to critically evaluate the practice of water fluoridation.
dc.identifier.urihttp://hdl.handle.net/10315/35502
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectEpidemiology
dc.subject.keywordsFluoride
dc.subject.keywordsPrenatal health
dc.subject.keywordsNeurodevelopment
dc.subject.keywordsNeurotoxicity
dc.subject.keywordsWater fluoridation
dc.subject.keywordsIQ
dc.titlePrenatal Fluoride Exposure and Neurodevelopmental Outcomes in a National Birth Cohort
dc.typeElectronic Thesis or Dissertation

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