The Effects of Beta-hydroxybutyrate and Glucose on Breast Cancer Cell Cycle Regulation and Metabolism

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dc.contributor.advisorConnor, Michael K.
dc.contributor.authorGodley, Linette Ann
dc.date.accessioned2023-10-03T20:04:43Z
dc.date.available2023-10-03T20:04:43Z
dc.date.issued2023-05
dc.date.updated2023-10-03T20:04:42Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractBreast cancer is a leading cause of death among women in Canada. Obesity is a major modifiable risk factor for many cancers, including breast cancer. Thus, managing body fatness is considered a potentially important intervention. The ketogenic diet (KD) has been garnering more attention as a novel cancer therapy due to its efficacy in inducing ketosis, a metabolic state resulting in reduced blood glucose, insulin and increased ketone bodies. When isolating the above mentioned KD-dependent circulatory changes my results show minor adaptive cellular responses in MCF7 and MDA-MB-468 cells, with no effect on overall cell cycle status. Overall there appears to be a trend to shifting metabolism, however it is likely that the major benefit from KD is mediated by the weight loss and changes in adipokine secretion profile that accompany KD, rather than the alterations in blood insulin, glucose and ketones in the circulation.
dc.identifier.urihttps://hdl.handle.net/10315/41444
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectHealth sciences
dc.subjectPhysiology
dc.subjectKinesiology
dc.subject.keywordsCancer
dc.subject.keywordsBreast cancer
dc.subject.keywordsGlucose
dc.subject.keywordsMCF7
dc.subject.keywordsKetogenic
dc.subject.keywordsKetosis
dc.subject.keywordsKetogenic diet
dc.subject.keywordsROS
dc.subject.keywordsOxidative stress
dc.subject.keywordsMetabolism
dc.subject.keywordsCancer cells
dc.subject.keywordsMDA-MB-468
dc.subject.keywordsTriple negative breast cancer
dc.titleThe Effects of Beta-hydroxybutyrate and Glucose on Breast Cancer Cell Cycle Regulation and Metabolism
dc.typeElectronic Thesis or Dissertation

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