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Delineating the Interaction Between TRAF1 and the Linear-Ubiquitin Chain Assembly Complex

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dc.contributor.advisorSater, Ali Abdul
dc.contributor.authorDhillon, Bipandeep Singh
dc.date.accessioned2020-05-11T12:57:46Z
dc.date.available2020-05-11T12:57:46Z
dc.date.copyright2019-12
dc.date.issued2020-05-11
dc.date.updated2020-05-11T12:57:46Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractTumour necrosis factor receptor (TNFR)-associated factor 1 (TRAF1) is a signaling adaptor that plays opposing roles in NF-B activation downstream of TNFR and Toll-like receptor (TLR) family members. Furthermore, TRAF1 has been associated with an increased risk of RA, however, the exact mechanisms regarding its role in RA are still unclear. Therefore, isolating its opposing effects on NF-B activation would provide an excellent model to study the exact role of TRAF1 in-vivo and in disease states such as RA and other inflammatory diseases, where multiple signaling pathways are involved. Since downstream of TLRs, TRAF1 negatively regulates NF-B by sequestering the Linear-Ubiquitin Chain Assembly Complex (LUBAC), we developed various TRAF1 truncations and mutants and by utilizing co-immunoprecipitation determined the exact protein-to-protein interaction between TRAF1 and LUBAC components. This will help create a TRAF1 mutant that does not associate with LUBAC, while maintaining its role in TNFR and other signaling pathways.
dc.identifier.urihttps://hdl.handle.net/10315/37487
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectImmunology
dc.subject.keywordsImmunology
dc.subject.keywordsInnate immune response
dc.subject.keywordsNF-KB
dc.subject.keywordsTRAFs
dc.subject.keywordsLUBAC
dc.subject.keywordsTRAF1
dc.subject.keywordsTNFR signaling
dc.subject.keywordsTLR signaling
dc.subject.keywordsRheumatoid arthritis
dc.titleDelineating the Interaction Between TRAF1 and the Linear-Ubiquitin Chain Assembly Complex
dc.typeElectronic Thesis or Dissertation

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