What generates flux of tubulin in kinetochore microtubules?

dc.contributor.authorForer, Arthur
dc.contributor.authorPickett-Heaps, Jeremy
dc.contributor.authorSpurck, Tim
dc.date.accessioned2021-02-22T21:22:57Z
dc.date.available2021-02-22T21:22:57Z
dc.date.issued2008-04
dc.description.abstractWe discuss models for production of tubulin flux in kinetochore microtubules. Current models concentrate solely on microtubules and their associated motors and enzymes. For example, in some models the driving force for flux is enzymes at the poles and the kinetochores; in others the driving force is motor molecules that are associated with a stationary spindle matrix. We present a different viewpoint, that microtubules are propelled poleward by forces arising from the spindle matrix, that the forces on the microtubules "activate" polymerising and depolymerising enzymes at kinetochores and poles, that matrix forces utilise actin, myosin, and microtubule motors, and that the matrix itself may not necessarily be static.en_US
dc.identifier.citationProtoplasma. 2008;232(3-4):137-41.en_US
dc.identifier.issn0033-183X
dc.identifier.urihttps://doi.org/10.1007/s00709-008-0286-yen_US
dc.identifier.urihttp://hdl.handle.net/10315/38112
dc.language.isoenen_US
dc.publisherSpringer Linken_US
dc.rightsSpringer This is a post-peer-review, pre-copyedit version of an article published in Protoplasma. 2008;232(3-4):137-41.. The final authenticated version is available online at: https://doi.org/10.1007/s00709-008-0286-y. More information on Springer Nature terms of reuse for archived author accepted manuscripts (AAMs) of subscription articles can be found at https://www.springer.com/gp/open-access/publication-policies/aam-terms-of-use.en_US
dc.rightsAttribution-NoDerivatives 4.0 International*
dc.rights.articlehttps://pubmed.ncbi.nlm.nih.gov/18421550/en_US
dc.rights.journalhttps://www.ncbi.nlm.nih.gov/en_US
dc.rights.publisherhttps://link.springer.com/en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/*
dc.subjectmitotic spindleen_US
dc.subjectspindle matrixen_US
dc.subjectmicrotubule dynamicsen_US
dc.subjectactinen_US
dc.subjectmyosinen_US
dc.titleWhat generates flux of tubulin in kinetochore microtubules?en_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
AAM.10.1007.s00709-008-0286-y.pdf
Size:
716.8 KB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.83 KB
Format:
Item-specific license agreed upon to submission
Description: