Effects Of Sustained Release Somatostatin Type 2 Antagonism On Glucagon Counterregulation And Glycemia In Type 2 Diabetic Rate Model

Simple item page
dc.contributor.advisorRiddell, Michael C.
dc.contributor.authorAleali, Nadia
dc.date.accessioned2025-04-10T10:42:14Z
dc.date.available2025-04-10T10:42:14Z
dc.date.copyright2024-08-15
dc.date.issued2025-04-10
dc.date.updated2025-04-10T10:42:13Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThis thesis examined whether a novel somatostatin receptor 2 antagonist (SSTR2a), ZT-01, could enhance endogenous glucagon secretion and protect against hypoglycemia in a rat model of type 2 diabetes (T2D). Male Sprague Dawley rats were placed on a high-fat diet and injected with streptozotocin to induce T2D. The rats were then chronically treated with varying doses of ZT-01 or vehicle using implanted mini-osmotic pumps. While ZT-01 did not significantly affect basal glucose levels or oral glucose tolerance, it tended to increase baseline glucagon levels and the glucagon response to insulin-induced hypoglycemia, though the effects were small. Overall, sustained exposure to SSTR2a modestly improved the glucose and glucagon response to insulin-induced hypoglycemia in this T2D model, suggesting the potential for this approach to prevent hypoglycemia in insulin-requiring T2D.
dc.identifier.urihttps://hdl.handle.net/10315/42749
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subject.keywordsDiabetes
dc.subject.keywordsType 2 Diabetes
dc.subject.keywordsPharmacology
dc.subject.keywordsDrug development
dc.subject.keywordsSomatostatin
dc.subject.keywordsGlucagon
dc.subject.keywordsInsulin
dc.subject.keywordsInsulin-requiring
dc.subject.keywordsOsmotic pumps
dc.subject.keywordsSustained-release
dc.subject.keywordsSomatostatin receptor 2 antagonist
dc.subject.keywordsSSTR2a
dc.titleEffects Of Sustained Release Somatostatin Type 2 Antagonism On Glucagon Counterregulation And Glycemia In Type 2 Diabetic Rate Model
dc.typeElectronic Thesis or Dissertation

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nadia_Aleali_2024_MSc.pdf
Size:
1.8 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.87 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
YorkU_ETDlicense.txt
Size:
3.39 KB
Format:
Plain Text
Description:
Download

Collections

Kinesiology & Health Science

All items in the YorkSpace institutional repository are protected by copyright, with all rights reserved except where explicitly noted.