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Investigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging

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dc.contributor.advisorIfa, Demian R.
dc.creatorBagga, Aafreen Kaur
dc.date.accessioned2019-03-05T14:58:44Z
dc.date.available2019-03-05T14:58:44Z
dc.date.copyright2018-12-06
dc.date.issued2019-03-05
dc.date.updated2019-03-05T14:58:44Z
dc.degree.disciplineChemistry
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe prevalence of fetal alcohol spectrum disorder (FASD) is increasing exponentially due to the in-cognizant consumption of alcohol during early pregnancy. This research primarily focuses on monitoring the variation of phospholipid distribution in various regions of the brain using DESI-MS imaging. FASD mouse models were used in this study in which alcohol was administered to the pregnant mice during first trimester and 30 day old offsprings were chosen for the analysis. Principal component analysis was performed on six samples that illustrated enhanced level of PC(16:0/16:0), PC (16:0/18:1) throughout the brain; while the level of PE(P-16:0/22:6), PS(18:0/18:1), PS(18:0/20:0), PS(18:0/22:6), PI(18:0/20:4) and ST(24:1) increased specifically in the white matter of the brain in response to alcohol consumption. Conversely, alcohol reduced the level of PC(16:0/18:1), PE(P-18:0/22:6) and PC(18:0/18:1) exclusively in white matter of the brain. The changes noted in various phospholipids lay strong foundation for understanding alcohol mediated biochemistry in fetal brain development.
dc.identifier.urihttp://hdl.handle.net/10315/35905
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectHealth sciences
dc.subject.keywordsFetal alcohol spectrum disorders
dc.subject.keywordsDESI-MS
dc.subject.keywordsdesorption electrospray ionization mass spectrometry imaging
dc.subject.keywordsimaging
dc.subject.keywordsfetal
dc.subject.keywordsbrain
dc.subject.keywordsmass spectrometer
dc.subject.keywordsalcohol
dc.subject.keywordsphospholipid
dc.titleInvestigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging
dc.typeElectronic Thesis or Dissertation

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