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The Immediate Early Response of Proliferating Myoblasts to One Bout of Electrical Stimulation

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dc.contributor.advisorConnor, Michael K.
dc.creatorTriolo, Matthew
dc.date.accessioned2017-07-27T12:31:08Z
dc.date.available2017-07-27T12:31:08Z
dc.date.copyright2016-09-27
dc.date.issued2017-07-27
dc.date.updated2017-07-27T12:31:08Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe maintenance of muscle mass is important across the lifespan. The activation of satellite cells, followed by their proliferation and subsequent differentiation is important in this maintenance. Cell cycle arrest must precede differentiation, and preservation of the molecular networks involved within the regenerative process are necessary. Electrical stimulation is a common method of altering activity within a cell, and is known to alter the phenotype of myogenic cells. This thesis looks at the immediate effects of electrical stimulation on proliferating C2C12 myoblasts, in order to determine what induces the long term reductions in cell number associated with electrical stimulation. The results indicate that stimulation alters intracellular processes within these cells, promoting cell cycle arrest and autophagy-mediated cellular remodelling, explaining the long term reduction in cell number associated with stimulation. The research conducted is important in our understanding of muscle regeneration and muscle health.
dc.identifier.urihttp://hdl.handle.net/10315/33403
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectCellular biology
dc.subject.keywordsSkeletal muscle
dc.subject.keywordsMuscle regeneration
dc.subject.keywordsMyogenesis
dc.subject.keywordsMuscle maintenance
dc.subject.keywordsCell cycle
dc.subject.keywordsMyogenic regulatory factors
dc.subject.keywordsAutophagy
dc.subject.keywordsElectrical stimulation
dc.subject.keywordsHuman physiology
dc.subject.keywordsCellular physiology
dc.titleThe Immediate Early Response of Proliferating Myoblasts to One Bout of Electrical Stimulation
dc.typeElectronic Thesis or Dissertation

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