Impacts of Empagliflozin (EMPA) Treatment on Skeletal Muscle Microvasculature in Type 1 Diabetic Rats

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dc.contributor.advisorRiddell, Michael C.
dc.contributor.authorEl-Zahed, Maya
dc.date.accessioned2022-12-14T16:23:35Z
dc.date.available2022-12-14T16:23:35Z
dc.date.copyright2022-06-15
dc.date.issued2022-12-14
dc.date.updated2022-12-14T16:23:35Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractIn individuals with type 1 diabetes (T1D) and models of the disease, hyperglycemia is associated with microvascular complications, including reduced capillary ratio in skeletal muscle (SM). We investigated whether a blood glucose lowering drug, empagliflozin (EMPA), has any impact on the microvasculature in SM. T1D was induced in eight-week-old male rats using streptozotocin (65 mg/kg, n=21). Twenty-one rats were given daily insulin and 11 of 21 rats also consumed EMPA (30 mg/kg/day) for 14 days. Twelve healthy non-diabetic rats served as controls. Capillary content and angiogenic factors were assessed in three separate leg muscles. EMPA+insulin treated rats exhibited better glycemic control, but capillary to fibre ratio and VEGFa mRNA was not impacted by EMPA+insulin treatment in the tibialis anterior. PECAM mRNA and VEGFa protein expression was also not impacted by EMPA+insulin treatment. EMPA has no obvious impact on the vasculature of SM in type 1 diabetic rodents.
dc.identifier.urihttp://hdl.handle.net/10315/40637
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectHealth sciences
dc.subjectPhysiology
dc.subject.keywordsDiabetes
dc.subject.keywordsType 1 diabetes
dc.subject.keywordsSkeletal muscle
dc.subject.keywordsSGLT2 inhibitor
dc.subject.keywordsSGLT2i
dc.subject.keywordsAngiognesis
dc.subject.keywordsCapillary health
dc.titleImpacts of Empagliflozin (EMPA) Treatment on Skeletal Muscle Microvasculature in Type 1 Diabetic Rats
dc.typeElectronic Thesis or Dissertation

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