Development of an Intelligent Heart-Cut Liquid Chromatography System for Chiral Analysis of Chemical Processes

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dc.contributor.advisorOrgan, Michael G.
dc.contributor.advisorPietro, William
dc.creatorBizzari, Nour Majid
dc.date.accessioned2018-05-28T12:47:59Z
dc.date.available2018-05-28T12:47:59Z
dc.date.copyright2017-11-03
dc.date.issued2018-05-28
dc.date.updated2018-05-28T12:47:59Z
dc.degree.disciplineChemistry
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractMulti-dimensional HPLC techniques enable researchers to monitor multiple essential and sometimes, critical quality attributes (CQAs) in parallel. A unique three-column, four-dimension liquid chromatography system employing a two-loop heart-cut strategy is reported. The system is capable of re-circulating effluents from each dimension through a single detector and performing heart-cut operations using a programmable ten-port, two-position heart-cut valve. The first dimension of analysis measures peak ratios of products to reagents while the second dimension offers peak purity of the heart-cut material. The third dimension uses a chiral column to measure the enantiomeric excess (ee) of the chiral analyte and the effluent from the third dimension is re-analyzed via a fourth dimension to determine if any loss of chirality has occurred resulting from the analytical method itself. Performance of the setup was evaluated using the synthesis of Warfarin as a model chemical process.
dc.identifier.urihttp://hdl.handle.net/10315/34502
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectOrganic chemistry
dc.subject.keywordsHPLC
dc.subject.keywordsMulti-dimensional
dc.subject.keywordsHeart-cut
dc.subject.keywordsWarfarin
dc.subject.keywordsAnalysis
dc.subject.keywordsQuality attributes
dc.subject.keywordsDrug development
dc.subject.keywordsProcess analytical technology
dc.subject.keywordsRecycling
dc.subject.keywordsChemical analysis
dc.subject.keywordsChirality
dc.subject.keywordsMACOS
dc.subject.keywordsReaction monitoring
dc.subject.keywordsFlow chemistry
dc.subject.keywordsAPI
dc.subject.keywordsBuchwald Hartwig Amination
dc.subject.keywordsAsymmetric Michael Addition
dc.subject.keywordsMultidimensional HPLC
dc.titleDevelopment of an Intelligent Heart-Cut Liquid Chromatography System for Chiral Analysis of Chemical Processes
dc.typeElectronic Thesis or Dissertation

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