Functional MRI Activation of Inhibitory Control in Adolescents and Young Adults with Multiple Sclerosis

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dc.contributor.advisorTill, Christine
dc.creatorLysenko, Magdalena
dc.date.accessioned2014-07-31T15:49:15Z
dc.date.available2014-07-31T15:49:15Z
dc.date.copyright2013-09-06
dc.date.issued2014-07-28
dc.date.updated2014-07-28T16:19:56Z
dc.degree.disciplinePsychology (Functional Area: Clinical-Developmental)
dc.degree.levelMaster's
dc.degree.nameMA - Master of Arts
dc.description.abstractInhibitory control, defined as the ability to withhold a response, is typically preserved in patients with multiple sclerosis (MS), despite impairment in other executive functions. This study examined the concept of functional reorganization concerning inhibitory control using a simple Go/No-go (GNG) functional MRI paradigm in pediatric-onset MS. The control group demonstrated greater functional activation as compared with the patient group in several regions: cerebellum, brainstem, lateral occipital cortex, parahippocampal gyrus, precuneus, superior parietal lobe, precentral gyrus and superior frontal gyrus. Cognitively intact pediatric-onset MS patients show less brain activation than controls when inhibiting a simple motor response despite no differences in behavioural performance. Functional differences were observed in the posterior and anterior regions of the response inhibition network in the MS group suggesting a less developed attention network. Further characterization of cerebellar-neocortical connectivity is required to understand the potential for functional plasticity in response to injury in pediatric-onset MS.en_US
dc.identifier.urihttp://hdl.handle.net/10315/27696
dc.language.isoenen_US
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectDevelopmental psychologyen_US
dc.subjectCognitive psychologyen_US
dc.subjectMedical imaging and radiologyen_US
dc.subject.keywordsExecutive functioningen_US
dc.subject.keywordsfMRIen_US
dc.subject.keywordsPediatric multiple sclerosisen_US
dc.subject.keywordsInhibitionen_US
dc.titleFunctional MRI Activation of Inhibitory Control in Adolescents and Young Adults with Multiple Sclerosisen_US
dc.typeElectronic Thesis or Dissertation

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