The Effects of Daytime Melatonin Administration on Sleep, Higher Cognitive Function, and Changes in the Brain

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dc.contributor.advisorSteel, Colin G.H.
dc.contributor.advisorDe Souza, Joseph F. X.
dc.creatorLeung, Samantha Eve
dc.date.accessioned2015-01-26T15:09:46Z
dc.date.available2015-01-26T15:09:46Z
dc.date.copyright2014-08-22
dc.date.issued2015-01-26
dc.date.updated2015-01-26T15:09:46Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThis study investigated the effects of exogenous melatonin on people’s sleep, ability to perform an emotional Stroop task, and underlying brain architecture. 10 healthy adults (age = 26.8 ± 6.25 years) underwent a baseline period followed by an experimental period whereby melatonin was administered at inappropriate times, with daily activity logs kept throughout. The emotional Stroop task was performed four times during each period, followed by an MRI scan. Following melatonin administration, sleep and wake times were significantly shifted and sleep quality ratings were significantly decreased compared to baseline values. Additionally, processing of emotional words but not faces was negatively affected by the melatonin treatment. Fractional anisotropy and mean diffusivity values were also significantly altered in the inferior frontal gyrus. It is inferred that the melatonin treatment induced circadian desynchronization, resulting in behavioural changes and structural alterations in brain regions involved in performance of the emotional Stroop task.
dc.identifier.urihttp://hdl.handle.net/10315/28270
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subjectNeurosciences
dc.subjectCognitive psychology
dc.subject.keywordsSleepen_US
dc.subject.keywordsCircadian biologyen_US
dc.subject.keywordsCircadian rhythmsen_US
dc.subject.keywordsMelatoninen_US
dc.subject.keywordsCognitionen_US
dc.subject.keywordsAttentionen_US
dc.subject.keywordsStroopen_US
dc.subject.keywordsInternal desynchronizationen_US
dc.subject.keywordsCircadian disruptionen_US
dc.subject.keywordsJet lagen_US
dc.subject.keywordsShift worken_US
dc.subject.keywordsDiffusion tensor imagingen_US
dc.subject.keywordsNeuroscienceen_US
dc.titleThe Effects of Daytime Melatonin Administration on Sleep, Higher Cognitive Function, and Changes in the Brain
dc.typeElectronic Thesis or Dissertationen_US

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