Investigating The Effect Of Chronic Muscle Use And Disuse On Innate Immune Signaling In Skeletal Muscle

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dc.contributor.advisorHood, David
dc.contributor.authorKhemraj, Priyanka
dc.date.accessioned2025-04-10T10:45:06Z
dc.date.available2025-04-10T10:45:06Z
dc.date.copyright2024-10-01
dc.date.issued2025-04-10
dc.date.updated2025-04-10T10:45:03Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractSkeletal muscle health is highly dependent on the intricate mitochondrial reticulum that exhibits high levels of adaptability. It is now recognized that mitochondrial perturbations can activate innate immune pathways, such as the NLRP3 inflammasome complex, by augmenting the response against damage-associated molecular patterns (DAMPs). The objective of this study was to investigate how various metabolic conditions affect innate immune activation and mitochondrial health within skeletal muscle, which has not been fully elucidated. To investigate this, we assessed innate immune signaling pathways and mitochondrial parameters within a model of muscle denervation and an aging model combined with endurance training. Our results suggest that NLRP3 inflammasome signaling is responsive to alterations in skeletal muscle activity and can be attenuated with chronic endurance training. Furthermore, we highlight a differential response to exercise with aged muscle in innate immune signaling. This work aims to further the understanding of innate immune signaling pathways within skeletal muscle, which can potentially highlight therapeutic targets to regulate its activation under divergent metabolic conditions.
dc.identifier.urihttps://hdl.handle.net/10315/42773
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subject.keywordsMitochondria
dc.subject.keywordsAging
dc.subject.keywordsDenervation
dc.subject.keywordsEndurance training
dc.subject.keywordsNLRP3 Inflammasome
dc.titleInvestigating The Effect Of Chronic Muscle Use And Disuse On Innate Immune Signaling In Skeletal Muscle
dc.typeElectronic Thesis or Dissertation

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