Investigating the Impact of Environmental Stressors on Skeletal Muscle Angio-Adaptation

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dc.contributor.advisorBirot, Olivier
dc.contributor.authorLemieux, Pierre Ferruccio Marcel
dc.date.accessioned2022-12-14T16:22:16Z
dc.date.available2022-12-14T16:22:16Z
dc.date.copyright2022-06-09
dc.date.issued2022-12-14
dc.date.updated2022-12-14T16:22:16Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractSkeletal muscle angio-adaptation refers to coordinated molecular and cellular events that regulate the expansion (angiogenesis) or regression of the muscle capillary network. The influence of environmental stressors (hypoxia, cold-stress) on skeletal muscle angio-adaptive responses are less understood in comparison to exercise-training or diseased states. This thesis addresses the influence of hypoxia and cold-stress on skeletal muscle angio-adaptation through a literature review and original research, respectively. After reviewing the literature, ambient hypoxia alone may be insufficient in improving muscle capillarization, however ambient hypoxia superimposed with exercise enhances the angiogenic response of exercise-training. In-vitro, the effect of cold-stress with respect to the angiogenic relationship between the myocyte and endothelial cell was investigated. Cold-stress reduced the secretion of angiogenic molecules from the myocyte. Furthermore, cold-stress abrogated endothelial cells proliferation and attenuated VEGFR2 activation. Endothelial cells pre-conditioned to cold-stress and challenged for migration in re-warming conditions however, exhibited an enhanced migratory responsiveness.
dc.identifier.urihttp://hdl.handle.net/10315/40629
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subject.keywordsSkeletal muscle
dc.subject.keywordsCapillary
dc.subject.keywordsAngiogenesis
dc.subject.keywordsVEGF-A
dc.subject.keywordsThrombospondin-1
dc.subject.keywordsHypoxia
dc.subject.keywordsAltitude
dc.subject.keywordsExercise
dc.subject.keywordsCold-stress
dc.subject.keywordsHypothermia
dc.subject.keywordsCold
dc.subject.keywordsProteome
dc.subject.keywordsMuscle cell
dc.subject.keywordsMyotubes
dc.subject.keywordsAngiokine
dc.subject.keywordsMyokine
dc.subject.keywordsAngiokine secretion
dc.subject.keywordsAngio-adaptation
dc.subject.keywordsMigration
dc.subject.keywordsProliferation
dc.subject.keywordsWestern blot
dc.subject.keywordsPCR
dc.subject.keywordsBoyden chamber
dc.subject.keywordsMyotube
dc.subject.keywordsVEGFR2
dc.subject.keywordsVEGF-R2
dc.subject.keywordsTHBS1
dc.subject.keywordsTHBS-1
dc.subject.keywordsTSP-1
dc.subject.keywordsVascular endothelial growth factor -A
dc.subject.keywordsVascular endothelial growth factor A
dc.subject.keywordsC2C12 myotubes
dc.subject.keywordsC2C12
dc.subject.keywordsEndothelial cells
dc.subject.keywordsEndothelial cell
dc.subject.keywordsSkeletal muscle endothelial cell
dc.subject.keywordsSMEC
dc.subject.keywordsmSMEC
dc.subject.keywordsMurine skeletal muscle endothelial cell
dc.titleInvestigating the Impact of Environmental Stressors on Skeletal Muscle Angio-Adaptation
dc.typeElectronic Thesis or Dissertation

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