The Role of ATF4 in Mediating Skeletal Muscle Function in Response to Acute Contractile Activity

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dc.contributor.advisorHood, David A.
dc.contributor.authorSanfrancesco, Victoria Carmela
dc.date.accessioned2023-12-08T14:35:32Z
dc.date.available2023-12-08T14:35:32Z
dc.date.issued2023-12-08
dc.date.updated2023-12-08T14:35:31Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractTo maintain homeostatic conditions under cellular stress, mitochondria possess the ability to initiate a nuclear retrograde signaling response to counteract the initial stressor and restore optimal organellar functioning. The Integrated Stress Response (ISR) is a newfound mitochondrial quality control stress mechanism that is activated in the face of intraorganellar stress and is capable of transducing various transcriptional responses in a manner dependent on the activating transcription factor 4 (ATF4). Mitochondrial homeostatic conditions can be challenged by acute contractile activity/exercise, activating the ISR. Using a mouse model, we sought to determine the responsiveness of the ISR and ATF4 to acute contractile activity of hindlimb muscle. Our data suggest that both the ISR and its effector, ATF4, are activated with contractile activity-induced stress at various stages. However, the precise mitochondrial stress that occurs with contractile activity and leads to the activation of the ISR and ATF4, remains to be elucidated.
dc.identifier.urihttps://hdl.handle.net/10315/41689
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subjectPhysiology
dc.subjectMolecular biology
dc.subject.keywordsATF4
dc.subject.keywordsMitochondria
dc.subject.keywordsSkeletal muscle
dc.subject.keywordsStress response
dc.subject.keywordsIntegrated stress response
dc.subject.keywordsAcute
dc.subject.keywordsExercise
dc.subject.keywordsContractile activity
dc.subject.keywordsSignaling
dc.subject.keywordsMolecular adaptations
dc.subject.keywordsISR
dc.subject.keywordsATF5
dc.subject.keywordsCHOP
dc.subject.keywordsUPRmt
dc.subject.keywordsHealth
dc.titleThe Role of ATF4 in Mediating Skeletal Muscle Function in Response to Acute Contractile Activity
dc.typeElectronic Thesis or Dissertation

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