Identifying Novel Interactions Between Human Ubiquitin-Specific Protease 7 (USP7) and Histone Methylating/Demethylating Proteins

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dc.contributor.advisorSaridakis, Vivian
dc.contributor.authorBojagora, Anna
dc.date.accessioned2022-08-08T15:40:42Z
dc.date.available2022-08-08T15:40:42Z
dc.date.copyright2020-06-29
dc.date.issued2022-08-08
dc.date.updated2022-08-08T15:40:42Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe deubiquitinase, Ubiquitin-Specific Protease 7 (USP7) is an indispensable protein responsible for regulating appropriate turnover of proteins involved in numerous signaling pathways and biological processes including immune response, DNA damage response, DNA replication, epigenetics and cell division. USP7s role in epigenetics is emerging and studies have demonstrated that USP7 modulates several epigenetic modifiers. This thesis further explores USP7s role in epigenetics, investigating USP7s novel regulation of two histone modifying enzymes highly implicated in oncogenesis, Enhancer of Zeste Homolog 2 (EZH2) and Retinoblastoma Binding Protein 2 (RBP2). Based on previous findings, our group identified probable interaction sites in these proteins and pursued to characterize the interactions and regulatory relationships.
dc.identifier.urihttp://hdl.handle.net/10315/39551
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiochemistry
dc.subject.keywordsUSP7
dc.subject.keywordsEZH2
dc.subject.keywordsPRC2
dc.subject.keywordsRBP2
dc.subject.keywordsKDM5A
dc.subject.keywordsJARID1A
dc.titleIdentifying Novel Interactions Between Human Ubiquitin-Specific Protease 7 (USP7) and Histone Methylating/Demethylating Proteins
dc.typeElectronic Thesis or Dissertation

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