Associations Between Urinary Concentrations of Non-Persistent Pesticide Exposure, Polycyclic Aromatic Hydrocarbons and Cardiometabolic Health

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dc.contributor.advisorKuk, Jennifer
dc.creatorRanjbar, Mahsa
dc.date.accessioned2015-01-26T15:01:09Z
dc.date.available2015-01-26T15:01:09Z
dc.date.copyright2014-08-21
dc.date.issued2015-01-26
dc.date.updated2015-01-26T15:01:09Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractRecent literature has established environmental pollutants to be associated with health risk. However, it remains unclear whether the less studied organophosphate (OP) pesticides and polycyclic aromatic hydrocarbons (PAH) influence cardiometabolic health independent of BMI. The first study in this thesis used 2,227 participants from the National Health and Nutrition Examination Survey (NHANES). It was demonstrated that most OPs are associated with a detrimental cardiometabolic health outcome with higher BMIs amplifying health risk. However one metabolite (dimethylphosphate) was associated with advantageous health outcomes. In the second study, 6,159 NHANES participants were used to demonstrate that high levels of PAH are positively and negatively associated with obesity. PAH was also associated with a greater risk of metabolic syndrome, dyslipidemia, hypertension, and type 2 diabetes, independent of BMI. Thus, OP and PAH influence obesity-related health risk, however, more research is needed to further elucidate the mechanistic pathways associated with OP, PAH and health.
dc.identifier.urihttp://hdl.handle.net/10315/28255
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectEpidemiology
dc.subjectEnvironmental science
dc.subjectHealth sciences
dc.subject.keywordsObesityen_US
dc.subject.keywordsOrganophosphate pesticideen_US
dc.subject.keywordsOPen_US
dc.subject.keywordsPolycyclic aromatic hydrocarbonsen_US
dc.subject.keywordsPAHen_US
dc.subject.keywordsCardiometabolic healthen_US
dc.subject.keywordsType 2 diabetesen_US
dc.subject.keywordsDyslipidemiaen_US
dc.subject.keywordsMetabolic syndromeen_US
dc.subject.keywordsHypertensionen_US
dc.subject.keywordsNHANESen_US
dc.subject.keywordsEnvironmental pollutanten_US
dc.subject.keywordsNon-persistent pesticideen_US
dc.titleAssociations Between Urinary Concentrations of Non-Persistent Pesticide Exposure, Polycyclic Aromatic Hydrocarbons and Cardiometabolic Health
dc.typeElectronic Thesis or Dissertationen_US

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