The Role of ATF5 in Mitochondrial Maintenance, Biogenesis and UPRmt Signaling Following Acute Exercise in Skeletal Muscle

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dc.contributor.advisorHood, David A.
dc.contributor.authorSlavin, Mikhaela Brodie
dc.date.accessioned2022-03-03T14:05:35Z
dc.date.available2022-03-03T14:05:35Z
dc.date.copyright2021-11
dc.date.issued2022-03-03
dc.date.updated2022-03-03T14:05:35Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractMaintenance of the mitochondrial protein folding environment is essential for organellar and cellular homeostasis. The Mitochondrial Unfolded Protein Response (UPRmt) is a protein quality control mechanism that relieves intraorganellar proteotoxic stress in a manner dependent on activating transcription factor 5 (ATF5) during mitochondrial dysfunction. Protein homeostasis can temporarily be disrupted by acute exercise, inducing the UPRmt. Using WT and whole-body ATF5 KO animals, we sought to determine the role of ATF5 in regulating basal mitochondrial content and function, in addition to acute exercise-induced changes in UPRmt signaling. Our data reveal that ATF5 is required in the maintenance of a high-quality mitochondrial pool and mediating the transcription of UPRmt genes during exercise. However, the specific mechanisms by which ATF5 and the UPRmt coordinate the preservation of mitochondrial homeostasis and whether they are required in mediating mitochondrial adaptations to chronic exercise are avenues of future work.
dc.identifier.urihttp://hdl.handle.net/10315/39115
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectPhysiology
dc.subject.keywordsKinesiology
dc.subject.keywordsExercise physiology
dc.subject.keywordsMitochondria
dc.subject.keywordsSkeletal muscle
dc.subject.keywordsMitochondrial unfolded protein response
dc.subject.keywordsProtein folding
dc.subject.keywordsMitochondrial quality control
dc.subject.keywordsCell physiology
dc.titleThe Role of ATF5 in Mitochondrial Maintenance, Biogenesis and UPRmt Signaling Following Acute Exercise in Skeletal Muscle
dc.typeElectronic Thesis or Dissertation

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