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Effect of Lipotoxicity on ER Stress, Autophagy and Apoptosis in Skeletal Muscle and Regulation by Adiponectin
Obesity is a key factor contributing to the “metabolic syndrome” which increases the risk for type 2 diabetes, cardiovascular disease and liver complications. In obese conditions, lipotoxicity is a serious concern as the ...
The Effects of LCN2 and Iron on Cardiac Remodeling and the Impact on Cardiac Function
Lipocalin-2 (Lcn2; also termed neutrophil gelatinase-associated lipocalin (NGAL)) is a proinflammatory factor which is elevated in obese individuals. It has also been implicated in the pathogenesis of heart failure and as ...
The Role of BRAP-2 in Caenorhabditis Elegans DNA Damage Induced Germline Apoptosis Development and Germline Health
The DNA damage response protects the genome by executing processes that prevent the disruption of normal cell physiology and the inheritance of mutations. BRCA1 is an essential tumor suppressor gene that facilitates DNA ...
Investigation of EPO-Mediated Rescue From P53-Dependent Apoptosis in DA3-EPOR Cells
The usage of recombinant human erythropoietin in clinics to treat cancer-associated anemia has shown unfortunate unforeseen tumour response to cytokine treatment. Although other cytokines have previously been shown to have ...
Investigation of Mechanisms Responsible for Myocyte Cell Death in Metabolic Syndrome
The aim of study is to investigate the mechanism involved in myocyte cell death in metabolic syndrome. Specific metabolic syndrome conditions focused on in this research are iron overload and hyperglycemia. Both in skeletal ...
The Role of CDCA7 in Akt-mediated Myc-Dependent Apoptosis and Proliferation
CDCA7, or cell division cycle associated protein A7, was described in 2001 by Prescott and colleagues as a target of Myc-dependent transcriptional regulation (Prescott et al., 2001). We have identified CDCA7 as associating ...