Now showing items 1-6 of 6
Mechanisms of High Insulin and High Glucose-Induced Skeletal Muscle Insulin Resistance: Focus on Regulation by Adiponectin
Skeletal muscle insulin resistance is known to play an important role in the pathogenesis of diabetes, however the cellular processes involved are poorly defined. Autophagy, ER stress, the UPR and oxidative stress are being ...
Effect of Lipotoxicity on ER Stress, Autophagy and Apoptosis in Skeletal Muscle and Regulation by Adiponectin
Obesity is a key factor contributing to the “metabolic syndrome” which increases the risk for type 2 diabetes, cardiovascular disease and liver complications. In obese conditions, lipotoxicity is a serious concern as the ...
Regulation of Cardiac Remodelling by Adiponectin in Response to Pressure Overload and Unloading: A Focus on the Extracellular Matrix
Cardiac remodelling, the reorganization of the heart which occurs in response to factors impacting its function, includes remodelling of the extracellular matrix (ECM) and hypertrophic cardiomyocyte growth. Pressure overload ...
The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance
Recent research is aiming to elucidate the molecular mechanisms of metabolic syndrome-associated diseases. This study investigates iron overload-induced adiponectin resistance in cardiovascular disease and diabetes. Iron ...
Investigate of Changes in Glucose Homeostasis by Modulating Endothelial Permeability
Altered permeability of the endothelial barrier in a variety of tissues has implications both in disease pathogenesis and treatment. Glucocorticoids are potent mediators of endothelial permeability and this forms the basis ...
Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
Unbalanced energy intake over expenditure causes obesity, and the prevalence and incidences of obesity have increased over last decades. People with obesity have a cluster of metabolic co-morbidities called metabolic ...