Department of Chemistry
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Collection consists of research, scholarship and publications produced by graduate students and faculty members of the Department of Chemistry.
Recent Submissions
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NMR for non-experts; a practical guide for applying NMR methods in studies of aptamer-ligand interactions
(2020-09-29)Nuclear Magnetic Resonance (NMR) Spectroscopy is a powerful technique for studying aptamer structure and function. Important information about ligand binding and how binding affects aptamer structure can be obtained ... -
Isothermal titration calorimetry studies of aptamer-small molecule interactions: practicalities and pitfalls
(2018-06-12)Isothermal titration calorimetry (ITC) is a powerful technique for studying binding interactions. From a single ITC experiment it is possible to quantify the affinity and thermodynamics of a binding event. Here, we outline ... -
Aptamers 2019 – a conference update
(2019-07-14)The International Society on Aptamers held Aptamers 2019, the sixth successful annual symposium at Oxford in April. The meeting was chaired by Professor Dr Günter Mayer. The participants, representing over 25 countries, ... -
Aptamers 2018 – a conference update
(2018-06-29)The 5th annual symposium of the International Society on Aptamers, Aptamers 2018, was held in Oxford on the 11th and 12th April. We had a very diverse group of attendees and presenters from all over the world with ... -
Aptamers 2017 at Oxford
(2018-02-12)The 4th annual symposium of the International Society on Aptamers, Aptamers 2017, was held in Oxford on the 11th and 12th April and was well attended, with presenters from Europe (Spain, Germany, Austria, and UK), North ... -
The minimum aptamer publication standards (MAPS guidelines) for de novo aptamer selection
(2022-05-24)Aptamers were first described in 1990 and since then many aptamers have been reported in the literature for numerous applications in both diagnostics and therapeutics. However, as with most fields, missing or unclear ... -
Cooperative binding by a bifunctional deoxycholic acid and cocaine-binding aptamer
(2021-11-17)A bifunctional cocaine and deoxycholic acid-binding aptamer was constructed from the individual ligand binding aptamers and the binding affinity and thermodynamics were measured using isothermal titration calorimetry. We ... -
Size-resolved particle measurements of polybrominated diphenyl ethers indoors: Implications for sources and human exposure
(Wiley, 2017-09-11)Polybrominated diphenyl ethers (PBDEs) are flame retardant polymer additives that are widely detected in outdoor and indoor environments. Release of PBDEs from consumer products leads to high concentrations indoors, but ... -
Formation and emission of hydrogen chloride in indoor air
(Wiley, 2018-10-04)To improve our understanding of chlorine chemistry indoors, reactive chlorine species such as hydrogen chloride (HCl) must be analyzed using fast time-response measurement techniques. Although well studied outdoors, sources ... -
Composition of size-resolved aged boreal fire aerosols: Brown carbon, biomass burning tracers, and reduced nitrogen
(ACS Publications, 2018-02-06)Aerosols that were size-resolved into 13 fractions between 10 nm and 18 μm were collected from an aged boreal forest wildfire plume in July 2013. Samples were extracted into water and analyzed for molecular-size-resolved ... -
Understanding sources of atmospheric hydrogen chloride in coastal spring and continental winter
(ACS Publications, 2021-08-18)Ambient 0.5 Hz hydrogen chloride (HCl) measurements were made in Canadian cities to 17 investigate chlorine activation and constrain the tropospheric chlorine budget. Springtime HCl mixing ratios in a coastal city (St. ... -
Lewis acids and bases as molecular dopants for organic semiconductors
(Wiley, 2020-05-05)Controlling the concentration of charge carriers (mobile electrons and holes) in organic semiconductors is vital to precisely controlling their electronic properties. Significant efforts have gone into understanding how ... -
A boron dipyrromethene (BODIPY) based probe for selective passive sampling of atmospheric nitrous acid (HONO) indoors
(Royal Society of Chemistry, 2021-08-23)People spend up to 90 % of their time indoors, and yet our understanding of indoor air quality and the chemical processes driving it are poorly understood, despite levels of key pollutants typically being higher indoors ... -
Poly(5-vinylbenzothiadiazole) for High-Performance Lithium-Ion Batteries
(American Chemical Society, 2019-09-18)Redox-active polymers have recently become promising candidates for next- generation electrode materials in lithium ion batteries. Materials made from small molecules with one or multiple reversible redox states are required ... -
Phosphaviologen-based Pyrene-Carbon Nanotube Composites for Stable Battery Electrodes
(2020-03-04)The adoption of intermittent renewable power sources has placed battery technologies into the limelight, initiating a push to develop sustainable materials for energy storage that do not rely on rare or toxic elements. ... -
The ice-vapor interface during growth and sublimation
(N/A, 2021)We employed Environmental Scanning Electron Microscopy (ESEM) in water vapor to study the complete scenario of ice growth, coalescence of crystallites, polycrystalline film morphology and sublimation, in the temperature ... -
Synthesis of a Trivalent P-Chloro-Dithienophosphole and its Reactivity with Organometallic Reagents
(Wiley, 2019-03-25)P-chloro-dithieno[3,2-b:2’,3’-d]phosphole was synthesized and isolated from the reaction of an aminophosphole and HCl. Developed to act as a common starting material for P-functionalized phospholes, the compound exhibits ... -
General formalism of vibronic Hamiltonians for tetrahedral and octahedral systems: problems that involve A-type states and a-type vibrations
(Elsevier, 2018-11-14)In this work, we derive expansion formulas up to arbitrary order in vibrational coordinates for the tetrahedral and octahedral vibronic Hamiltonians that involve A-type states and a-type vibrations. The root-branch approach ... -
Diradical Character as a Guiding Principle for the Insightful Design of Molecular Nanowires with an Increasing Conductance with Length
(American Chemical Society, 2018-10-22)In recent years, a considerable interest has grown in the design of molecular nanowires with an increasing conductance with length. The development of such nanowires is highly desirable since they could play an important ... -
Electronegativity Seen as the Ground State Average Valence Electron Binding Energy
(American Chemical Society, 2018-11-30)We introduce a new electronegativity scale for the atoms, based consistently on ground state energies of valence electrons. The scale is closely related to (yet different from) L.C. Allen’s, which is based on configuration ...
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