Chemistry
Soumissions récentes
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Development, Validation, and Application of Methods for High Time-Response Measurement of Gaseous Atmospheric Chlorinated Species
(2022-03-03)Halogenated compounds that participate in catalytic cycles in the atmosphere can influence the fate of chemicals, including ozone, methane, and volatile organic compounds (VOCs). These halogen radicals, in particular atomic ... -
Estimating Methane Emissions in Canada Using Atmospheric Observations from Earth to Space
(2022-03-03)Methane is a significant greenhouse gas with 25–32 times the global warming potential of carbon dioxide. Global sources and sinks of methane are understood to be 550 ± 60 Tg a-1. The possible causes of changing decadal ... -
Crystallization Studies of the TraF Protein from the F Plasmid of Escherichia coli
(2022-03-03)Crystallization of suitable crystals for diffraction analysis is a major hurdle in structure-function studies of proteins using X-ray crystallography. This is especially true when the protein may be generally hydrophobic, ... -
Thermodynamic and Kinetic Analysis of Aptamer-Ligand Interactions Using Isothermal Titration Calorimetry
(2022-03-03)Aptamers are short single-stranded DNA or RNA oligonucleotide sequences capable of binding to a broad range of target molecules with high affinity and specificity. They can interact with a large variety of targets such as ... -
Probing the Impact of Solvent on Lewis Acid Catalysis via Fluorescent Lewis Adducts
(2021-11-15)Over the years, various multiparameter methods have been developed to measure the strength of a Lewis acid. However, a major challenge for these measurements lies in the complexity that arises from variables, such as solvent ... -
Insights into Genipin Dye Mechanisms and Colour Origins
(2021-11-15)Genipin is a natural compound that forms colours when reacted with primary amines. Curiously, it contains a large amount of uncertainty surrounding its dye structure. It was previously believed that genipin reacts with ... -
Functionalization of 4-Substituted Pyridines for Enantioselective Synthesis
(2021-07-06)Enantioselective synthesis using nitrogen containing heterocycles, such as pyridines, is extremely useful in drug discovery. The prevalence of pyridines in the drug market is well-documented and a mild, enantioselective ... -
Development of New and Modification of Existing Methods for the Primary Screening of Aptamers and Antibodies by Means of Capillary Electrophoresis
(2021-03-08)Discovery of new drugs starts with screening a library of drug candidates (ligands) for their ability to bind targets. Such a screening can be conducted by a variety of analytical techniques; however, Capillary Electrophoresis ... -
Palladium-Catalyzed Functionalization of 4-Alkylpyridines: Pyridlyic Dehydrogenation & Mechanistic Investigation of Pyridylic Allylation
(2021-03-08)Pyridines are important frameworks in drug development, valued for their ubiquitous presence in biologically active compounds. As such, we have taken a keen interest in developing mild methods for pyridylic functionalization ... -
Chemical Profiling of Drugs and Metabolites from Complex Biological Matrices by Atmospheric Pressure and Ambient Ionization Mass Spectrometry
(2020-11-13)Atmospheric pressure and ambient mass spectrometry (MS) techniques are powerful analytical tools for the omics technologies. Ambient MS techniques allow for the surface analysis of molecules directly from substrates and ... -
Hamiltonian Formalism of Spin-Orbit Jahn-Teller and Pseudo-Jahn-Teller Problems in Trigonal and Tetragonal Symmetries
(2020-11-13)A formalism for expansions of all bimodal spinorbit JahnTeller and pseudo-JahnTeller Hamiltonian operators in trigonal and tetragonal symmetries is presented. With the formalism, we can easily obtain expansion formulas of ... -
Optimizing the Toehold-Mediated Strand Displacement Reaction on the Nanoparticle Surface by Altering the Surface DNA Density for the Design of a microRNA NanoOptical Sensor
(2020-11-13)We present a method for modulating the kinetics and thermodynamic properties of aggregation and disassembly processes of DNA-functionalized nanoparticles. Specifically, we examine factors influencing the toehold ... -
Thermodynamic Analysis of Aptamer-Ligand Binding by Isothermal Titration Calorimetry
(2020-08-11)Aptamers are short, single stranded nucleic acid molecules typically 15 to 60 nucleotides in length with the capacity of binding diverse molecular targets, ranging from small molecules to whole cells primarily due to their ... -
Structural Mass Spectrometry Analysis of RNA Chaperones and Protein Therapeutics
(2020-08-11)Since the advent of soft ionization techniques, most notably electrospray ionization (ESI), the application of mass spectrometry (MS) analysis has expanded to intact biomolecules. ESI-MS gave rise to the field of structural ... -
Mild and Selective Palladium-Catalyzed Pyridylic Allylation of 4-Alkylpyridines
(2020-08-11)Pyridines and related heterocycles enjoy widespread occurrence in biologically relevant natural products and drug-like molecules. Therefore, new methods that facilitate their synthesis and incorporation into drug-like ... -
Synthesis of New Titanium Complexes Bearing a Bidentate Monoanionic Inversely-Polarized Phosphaalkene-Enolate Ligand and their Activity in Olefin Polymerization
(2020-05-11)The synthesis and characterization of several inversely-polarized phosphaalkenes, including the first ring-expanded inversely-polarized hydrido-phosphaalkene and imidazolidine-based inversely-polarized phosphaalkene-enolate ... -
Performance of Nanostructured Ternary Metal Spinel Oxides as Efficient Electrocatalysts
(2020-05-11)In this work, various spinel oxides, namely Ni1-xCuxCo2O4 (0 x 0.75), Fey(Ni/Cu)x-y Co3-xO4 [(0.5 x 1), (0.1 y 0.15)] have been prepared on Fluorine coated Tin Oxide (FTO) glass by the thermal decomposition method. ... -
Novel Olefin Polymerization Pre-Catalyst Bearing an Inversely-Polarized Phosphaalkene Ethenolate Monoanionic Bidentate Ligand and its Polymerization Studies
(2020-05-11)The synthesis and structure elucidation of the first monoanionic bidentate ligand bearing an inversely-polarized phosphaalkene, its precursors and the first titanium complex bearing such ligand are herein reported. ... -
The Total Synthesis of () 7-HDHA
(2020-05-11)Fatty acid () 7-HDHA was recently identified as an endogenous ligand for PPAR/ receptors by one of our collaborators Dr. Henry Krause group. While this discovery is promising in understanding PPARs mechanism of effects and ... -
Characterizing Conformational Dynamics and Catalytic Activity of Enzymes by Hydrogen-Deuterium Exchange Mass Spectrometry
(2019-11-22)Determining the conformational dynamics of enzymes as they undergo catalysis has been challenging for decades due to the short timescale and limitations of traditional analysis, including techniques such as CPMG 2D NMR and ...
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