Chemistry
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Characterizing Conformational Dynamics and Catalytic Activity of Enzymes by Hydrogen-Deuterium Exchange Mass Spectrometry
(2019-11-22)Determining the conformational dynamics of enzymes as they undergo catalysis has been challenging for decades due to the short timescale and limitations of traditional analysis, including techniques such as CPMG 2D NMR and ... -
Using PNA Probes for Hybridization-Based Analysis of miRNAs in Capillary Electrophoresis
(2019-11-22)The inherent separation inefficiencies of the excess probes and hybrids and the hybrids from each other limits the use of capillary electrophoresis (CE) for hybridization-based analysis of microRNA (miRNAs). Our lab developed ... -
Characterization, Imaging and Quantitation of Small Molecules by Ambient Ionization Mass Spectrometry
(2019-11-22)For more than a century mass spectrometry has been a well-known technique in the field of chemical analytics. Its selectivity and sensitivity has made it popular in various fields. From analysis of pure organics, its use ... -
Mass Spectrometry Methods for Enhanced Characterization of Biological Systems
(2019-07-02)As the pharmaceutical industry moves towards larger protein-based therapeutics over chemically synthesized small molecules, there are increasing demands for parallel advancement in the technologies used for quality control ... -
Characterizing the Structure-Function Relationship of Pathological Proteins
(2019-07-02)Protein structure and dynamics dictate the fundamentals of protein function. For example, a structured protein must change its conformation when interacting with various ligands. In addition, misfolded or intrinsically ... -
Comparing Solution-Phase and Gas-Phase Protein Stability Using Ion Mobility and Differential Mobility Mass Spectrometry
(2019-07-02)A critical quality attribute for many proteins concerning biopharmaceutical products is the proteins stability. Current stability assays are lengthy but some quick stability assays to determine the proteins melting temperature ... -
Iron-Doped Titanium Dioxide Nanomaterials: Synthesis, Characterization and Photodegradation Catalytic Behavior
(2019-07-02)Titanium dioxide (TiO2) is a very good material for various photocatalytic industrial applications because of its non-toxicity, high chemical stability, low cost and relatively good photoactivity. However, one of the most ... -
The Measurement of Atmospheric Species with Absorptions Close to the Actinic Flux Cut-Off by Active & MAX-DOAS: Chlorine Monoxide (CIO) & Sulphur Dioxide (SO2)
(2019-07-02)The gas-phase chlorine monoxide (ClO) radical has been studied extensively for its role in catalytic stratospheric ozone depletion following the discovery of the Antarctic ozone hole in 1985. Reactive chlorine chemistry ... -
Application of Pd-NHC Complexes in Challenging Amination Reactions
(2019-07-02)Among Pd-catalyzed carbon-heteroatom cross-coupling reactions, C-N bond formation, known as Buchwald-Hartwig amination (BHA), is by far the most studied reaction owing to the prevalence of arylated amines in pharmaceuticals, ... -
Charge Transfer in Poly (3-Hexylthiophene) / Titanium Dioxide Inverse Opals: Effects of Surface Passivation and Donor Concentration
(2019-07-02)Hybrid photovoltaics are attractive because of their low cost and ability to be applied onto flexible substrates. However defect states can trap charges and are undesirable. We investigate TiO2 inverse opals treated with ... -
Synthesis and Reactivity of Umpolung Reagents Through Transition Metal Catalysis
(2019-03-05)The cyclopropanol-derived palladium-homoenolates have previously been exploited as a unique class of cross-coupling partners in our group. The major advantage of using cyclopropanols as the cross-coupling partners is the ... -
Investigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging
(2019-03-05)The prevalence of fetal alcohol spectrum disorder (FASD) is increasing exponentially due to the in-cognizant consumption of alcohol during early pregnancy. This research primarily focuses on monitoring the variation of ... -
Determining Emission Factors from Marine Vessels Employing Differential Optical Absorption Spectroscopy (DOAS) and Tunable Diode Laser Absorption Spectroscopy (TDLAS)
(2019-03-05)High SO2 concentrations are harmful to human health and impact climate by affecting cloud formation. Ship contrails are the major source of SO2 in the open-ocean and impact coastal region air quality. The International ... -
Unravelling the Conformational Dynamics of a-Synuclein's Folding Pathway By Hydrogen-Deuterium Exchange Mass Spectrometry in the Presence of Phospholipid Nanodiscs
(2019-03-05)Conformational changes of the -synuclein protein during docking into a phospholipid membrane is suspected to play a central role in neuronal cell death during Parkinsons disease. This intrinsically disordered protein obtains ... -
Silica Sol-Gel Materials as a Catalyst Support for Use in Microwave-Assisted Continuous-Flow Organic Synthesis
(2019-03-05)The Organ group used microwave irradiation as a means of heating flowed chemical reactions in the development of a microwave-assisted continuous-flow organic synthesis (MACOS) system, to combine the benefits of flow reactions ... -
Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation
(2019-03-05)Continuous microfluidic technology has proven to be a potential competitor with established batch systems for facilitating chemical synthesis and purification, and more amenable to miniaturization, integration, and automation. ... -
Part I: Palladium PEPPSI-IPENT CI, A Useful Catalyst for Challenging Amination Reactions Part II: Generation Of Benzynes in Flow Reactors followed by Subsequent Diels-Alder Reactions
(2018-08-27)The first part of this research focuses on developing efficient methods to address challenging Buchwald Hartwig amination reactions using Pd-NHC pre-catalysts. Specifically, we focused on: a) coupling of sterically hindered ... -
A Novel Ground Based Mass-Balance Method for Methane Emission Quantification
(2018-08-27)Emission of CH4 from landfills in Canada are not well constrained and in Ontario constitute the largest point source emitters. The purpose of this study was to develop and test a ground based method for quantifying CH4 ... -
Collison-Induced Dissociation of 4-imidazolone Ions; Isomers of [bn]+ Derived from Peptides After Water Loss
(2018-08-27)Collision-induced dissociation spectra of protonated peptides [(aminoacid)n + H]+ form, after the loss of water, nominal [bn]+ ions which are dependent on both peptide length and amino acid sequence. Protonated tetraglycine ... -
Fragmentation of Lanthanide (III) Cationized Small Peptides: Generation of Peptide Radical Cations and Dipositive a and b ions.
(2018-08-27)This research work examines the dissociation chemistry of tripositive complexes formed by trivalent lanthanide ions and small peptides with tandem mass spectrometry under low-energy collision-induced dissociation (CID). ...
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