Now showing items 11-15 of 15
Structural Studies of the Receiver Domain of LytR from Staphylococcus Aureus and Interaction Studies of TraW and TrbC from the F Plasmid of Escherichia Coli
The emergence of the multi-drug resistant bacteria and the evolutionary spread of the antibiotic resistance genes have become a great concern to human health. Bacteria use various systems in combination or alone in response ...
Synthesis of Novel Cyclobutane Nucleoside Analogues
A synthesis of cyclobutane nucleosides is described. The method involved the triflation of a -hydroxymethyl-cyclobutanone and its subsequent displacement by a 6-chloropurinyl anion to generate N-7 and N-9 regioisomers. ...
Characterizing the Structure-Function Relationship of Pathological Proteins
Protein structure and dynamics dictate the fundamentals of protein function. For example, a structured protein must change its conformation when interacting with various ligands. In addition, misfolded or intrinsically ...
Front-End Methods For Enhancing the Analytical Power of Mass Spectrometry
The analytical power and versatility of mass spectrometry can be enhanced by adding front-end devices, which provide additional functionality before, during or immediately after ElectroSpray Ionization (ESI). Such devices ...
The Cocaine-Binding Aptamer: A Thermodynamic and Structural Overview of Specific and Non-Specific Binding Interactions
Isothermal Titration Calorimetry (ITC) studies were conducted wherein variances in the heat capacity of binding (Cp) among variants of the cocaine-binding aptamer were suggestive of two distinct binding mechanisms. Aptamer ...