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Synthesis, Characterization and Reactivity Study of Bis (Imino)-N-Heterocyclic Carbene Transition Metal Complexes
(2015-08-28)
Three generations of the first 1,3-bis(imino) N-heterocyclic carbene (NHC) ligand precursors were synthesized, isolated and characterized. The synthetic methodologies of the ligand precursors were controlled by the iminic ...
Biomedical Characterization of the WalKR and the LytSR Two Component System From Staphylococcus Aureus
(2015-08-28)
Staphylococcus aureus is a major gram-positive pathogen, because of its remarkable capacity to develop resistance against different antimicrobial agents. It has been shown that in S. aureus two component systems (TCS) ...
Development of an Intelligent Heart-Cut Liquid Chromatography System for Chiral Analysis of Chemical Processes
(2018-05-28)
Multi-dimensional HPLC techniques enable researchers to monitor multiple essential and sometimes, critical quality attributes (CQAs) in parallel. A unique three-column, four-dimension liquid chromatography system employing ...
Development of Microfluidic Devices for Studying Protein Conformational Dynamics via HDX/TRESI-MS
(2014-07-28)
Studies of protein conformational dynamics can lead to a deeper understanding of biological functions of proteins, protein/protein interactions, catalysis and allostery. Most of the conformers involved in biological pathways ...
Examining the Effect of Poly (Ethylene glycol) and Non-Specific Insulin Binding on the Phase Behaviour of PEGylated Phosphocholine Membrane Models
(2016-11-25)
Inclusion of synthetic poly-(ethylene glycol) (PEG)-grafted phospholipids into self-assembled phospholipid matrices is an exceptional method to engineering optimized bio-non-fouling membrane mimetic surfaces. The success ...
Isomerization and Fragmentation of [b5]+ IONS AND [b5 H]+ Radical Cations in the Gas Phase
(2018-03-01)
In this thesis, we examined the CID spectra of the closed-shell [A4W-Me oxa + H]+ ions, which are completely identical, and indicates sequence scrambling. There are some unique fragmentation patterns from this set of ions ...
Collison-Induced Dissociation of 4-imidazolone Ions; Isomers of [bn]+ Derived from Peptides After Water Loss
(2018-08-27)
Collision-induced dissociation spectra of protonated peptides [(aminoacid)n + H]+ form, after the loss of water, nominal [bn]+ ions which are dependent on both peptide length and amino acid sequence. Protonated tetraglycine ...
Characterization of Structures and Dynamics of Intrinsically Disordered Domain and Proteins Using Time Resolved-Hydrogen Deuterium Exchange Mass Spectrometry
(2017-07-27)
Proteins are inherently dynamic. Virtually all of the processes that underlie biological activity, including binding partner recognition, catalysis and allostery among many others, require transient adoption of specific ...
Part I: Mechanistic Insight in Alkyl-Alkyl and Aryl-Aryl Negishi Cross-Coupling Part II: Large Scale Synthesis of NHC Precursors: 2,6-DI(3-Pentyl) Aniline and 2,6-DI (4-Heptyl) Aniline
(2016-09-20)
Part I: An efficient method for alkyl-alkyl Negishi cross-coupling reaction of unactivated primary alkyl halides with higher-order zincate species (synthesized from dialkylzinc and a non-coordinating halide salt in situ) ...
Development of a New General Click Chemistry and Applications in Bioconjugation: Part I: Rewiring Bacteria Cell Surfaces with Bio-Orthogonal Chemistry Part II: A Novel General Dialdehyde Click Chemistry for Primary Amine Conjugation
(2018-03-01)
The ability to tailor cell surfaces with non-native molecules is critical to advance the study of cellular communication, cell behavior, and for next-generation therapeutics. There has been tremendous effort to tailor ...