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Unravelling the Conformational Dynamics of a-Synuclein's Folding Pathway By Hydrogen-Deuterium Exchange Mass Spectrometry in the Presence of Phospholipid Nanodiscs
(2019-03-05)
Conformational changes of the -synuclein protein during docking into a phospholipid membrane is suspected to play a central role in neuronal cell death during Parkinsons disease. This intrinsically disordered protein obtains ...
Silica Sol-Gel Materials as a Catalyst Support for Use in Microwave-Assisted Continuous-Flow Organic Synthesis
(2019-03-05)
The Organ group used microwave irradiation as a means of heating flowed chemical reactions in the development of a microwave-assisted continuous-flow organic synthesis (MACOS) system, to combine the benefits of flow reactions ...
Investigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging
(2019-03-05)
The prevalence of fetal alcohol spectrum disorder (FASD) is increasing exponentially due to the in-cognizant consumption of alcohol during early pregnancy. This research primarily focuses on monitoring the variation of ...
Determining Emission Factors from Marine Vessels Employing Differential Optical Absorption Spectroscopy (DOAS) and Tunable Diode Laser Absorption Spectroscopy (TDLAS)
(2019-03-05)
High SO2 concentrations are harmful to human health and impact climate by affecting cloud formation. Ship contrails are the major source of SO2 in the open-ocean and impact coastal region air quality. The International ...
Synthesis and Reactivity of Umpolung Reagents Through Transition Metal Catalysis
(2019-03-05)
The cyclopropanol-derived palladium-homoenolates have previously been exploited as a unique class of cross-coupling partners in our group. The major advantage of using cyclopropanols as the cross-coupling partners is the ...
Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation
(2019-03-05)
Continuous microfluidic technology has proven to be a potential competitor with established batch systems for facilitating chemical synthesis and purification, and more amenable to miniaturization, integration, and automation. ...
Charge Transfer in Poly (3-Hexylthiophene) / Titanium Dioxide Inverse Opals: Effects of Surface Passivation and Donor Concentration
(2019-07-02)
Hybrid photovoltaics are attractive because of their low cost and ability to be
applied onto flexible substrates. However defect states can trap charges and are
undesirable. We investigate TiO2 inverse opals treated with ...
Mass Spectrometry Methods for Enhanced Characterization of Biological Systems
(2019-07-02)
As the pharmaceutical industry moves towards larger protein-based therapeutics over chemically synthesized small molecules, there are increasing demands for parallel advancement in the technologies used for quality control ...
Application of Pd-NHC Complexes in Challenging Amination Reactions
(2019-07-02)
Among Pd-catalyzed carbon-heteroatom cross-coupling reactions, C-N bond formation, known as Buchwald-Hartwig amination (BHA), is by far the most studied reaction owing to the prevalence of arylated amines in pharmaceuticals, ...
The Measurement of Atmospheric Species with Absorptions Close to the Actinic Flux Cut-Off by Active & MAX-DOAS: Chlorine Monoxide (CIO) & Sulphur Dioxide (SO2)
(2019-07-02)
The gas-phase chlorine monoxide (ClO) radical has been studied extensively for its role in catalytic stratospheric ozone depletion following the discovery of the Antarctic ozone hole in 1985. Reactive chlorine chemistry ...