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Unravelling the Conformational Dynamics of a-Synuclein's Folding Pathway By Hydrogen-Deuterium Exchange Mass Spectrometry in the Presence of Phospholipid Nanodiscs
(2019-03-05)
Conformational changes of the -synuclein protein during docking into a phospholipid membrane is suspected to play a central role in neuronal cell death during Parkinsons disease. This intrinsically disordered protein obtains ...
Silica Sol-Gel Materials as a Catalyst Support for Use in Microwave-Assisted Continuous-Flow Organic Synthesis
(2019-03-05)
The Organ group used microwave irradiation as a means of heating flowed chemical reactions in the development of a microwave-assisted continuous-flow organic synthesis (MACOS) system, to combine the benefits of flow reactions ...
Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation
(2019-03-05)
Continuous microfluidic technology has proven to be a potential competitor with established batch systems for facilitating chemical synthesis and purification, and more amenable to miniaturization, integration, and automation. ...
Synthesis and Reactivity of Umpolung Reagents Through Transition Metal Catalysis
(2019-03-05)
The cyclopropanol-derived palladium-homoenolates have previously been exploited as a unique class of cross-coupling partners in our group. The major advantage of using cyclopropanols as the cross-coupling partners is the ...
Investigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging
(2019-03-05)
The prevalence of fetal alcohol spectrum disorder (FASD) is increasing exponentially due to the in-cognizant consumption of alcohol during early pregnancy. This research primarily focuses on monitoring the variation of ...
Determining Emission Factors from Marine Vessels Employing Differential Optical Absorption Spectroscopy (DOAS) and Tunable Diode Laser Absorption Spectroscopy (TDLAS)
(2019-03-05)
High SO2 concentrations are harmful to human health and impact climate by affecting cloud formation. Ship contrails are the major source of SO2 in the open-ocean and impact coastal region air quality. The International ...
Iron-Doped Titanium Dioxide Nanomaterials: Synthesis, Characterization and Photodegradation Catalytic Behavior
(2019-07-02)
Titanium dioxide (TiO2) is a very good material for various photocatalytic industrial applications because of its non-toxicity, high chemical stability, low cost and relatively good photoactivity. However, one of the most ...
Mass Spectrometry Methods for Enhanced Characterization of Biological Systems
(2019-07-02)
As the pharmaceutical industry moves towards larger protein-based therapeutics over chemically synthesized small molecules, there are increasing demands for parallel advancement in the technologies used for quality control ...
Charge Transfer in Poly (3-Hexylthiophene) / Titanium Dioxide Inverse Opals: Effects of Surface Passivation and Donor Concentration
(2019-07-02)
Hybrid photovoltaics are attractive because of their low cost and ability to be
applied onto flexible substrates. However defect states can trap charges and are
undesirable. We investigate TiO2 inverse opals treated with ...
Comparing Solution-Phase and Gas-Phase Protein Stability Using Ion Mobility and Differential Mobility Mass Spectrometry
(2019-07-02)
A critical quality attribute for many proteins concerning biopharmaceutical products is the proteins stability. Current stability assays are lengthy but some quick stability assays to determine the proteins melting temperature ...