Browsing Electronic Theses and Dissertations (ETDs) by Subject "Ubiquitin transfer mechanism"
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(2015-08-28)Human E3 ligase Mdm2 is an oncogene. Its amplification and overexpression have been found in many types of cancers. Mdm2 inhibits tumour suppressor p53 by regulating its stability through Mdm2 RING-mediated ubiquitination. ...