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Exploration of the Mitochondria as a Potential Therapeutic Target in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease resulting from a mutation in the X-linked gene encoding the protein dystrophin. DMD is characterized by profound muscle weakness as degenerating ...
The Effect of Acute and Chronic Exercise on Mitochondrial Respiratory Sensitivity to ADP in Human Skeletal Muscle
ADP/ATP is believed to either diffuse slowly between mitochondria and the cytosol or be substituted with fast diffusing creatine (Cr) and phosphocreatine (PCr) ‘phosphate shuttling’ catalyzed by mitochondrial creatine ...