The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance

Recent research is aiming to elucidate the molecular mechanisms of metabolic syndrome-associated diseases. This study investigates iron overload-induced adiponectin resistance in cardiovascular disease and diabetes. Iron overloaded primary neonatal cardiomyocytes, L6 skeletal muscle myoblasts, and an in vivo mouse model was used to examine adiponectin resistance. Data indicates the induction of adiponectin resistance after iron treatment, and that this may occur by changes in adiponectin signalling proteins via the regulation of FOXO1 transcription factor. A decrease in adiponectin sensitivity was not observed in the iron overload mouse model used here, although this may be dependent on amount and duration of iron overload. Overall, this study sheds light on the complex balance of adiponectin signalling under iron overload conditions in heart and skeletal muscle. The data indicates that iron can induce adiponectin resistance, and thus helps to elucidate the cellular mechanisms via which metabolic syndrome disease complications can occur.