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Functional Characterization of Pyrokinins and their Receptors in the Adult Mosquito, Aedes aegypti

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dc.contributor.advisorPaluzzi, Jean-Paul
dc.contributor.authorLajevardi, Aryan
dc.date.accessioned2020-08-11T12:36:35Z
dc.date.available2020-08-11T12:36:35Z
dc.date.copyright2020-01
dc.date.issued2020-08-11
dc.date.updated2020-08-11T12:36:35Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe mosquito Aedes aegypti is a common disease vector that continues to cause devastating harm to human populations. Mosquitoes owe much of their success to their excretory system, comprised of the Malpighian tubules and hindgut, which play important roles when faced with environmental and dietary challenges. Pyrokinins are a family of neuropeptides initially identified based on their ability to regulate hindgut physiology of other insects. In light of this knowledge, this thesis aimed to examine whether pyrokinins have similar roles in A. aegypti. Pyrokinin receptors were functionally characterized and receptor transcript expression profiles were determined to confirm the hindgut as a target organ for these neuropeptides. A pyrokinin-2 family member was found to reduce contractile activity of the anterior hindgut, which represents the first role established for pyrokinins in any blood-feeding arthropod. These findings suggest the importance of this neuropeptide family in regulating critical processes in this disease vector.
dc.identifier.urihttp://hdl.handle.net/10315/37675
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectEndocrinology
dc.subject.keywordsPyrokinin
dc.subject.keywordsNeuroendocrinology
dc.subject.keywordsG protein-coupled receptor
dc.subject.keywordsHeterologous receptor functional assay
dc.subject.keywordsHindgut
dc.subject.keywordsIleum
dc.subject.keywordsRectum
dc.subject.keywordsMotility
dc.subject.keywordsScanning Ion-selective Electrode Technique
dc.subject.keywordsInsect
dc.subject.keywordsMosquito
dc.subject.keywordsDisease vector
dc.titleFunctional Characterization of Pyrokinins and their Receptors in the Adult Mosquito, Aedes aegypti
dc.typeElectronic Thesis or Dissertation

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