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Investigate of Changes in Glucose Homeostasis by Modulating Endothelial Permeability

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dc.contributor.advisorSweeney, Gary
dc.creatorDang, Thanh Que
dc.date.accessioned2018-03-01T14:12:44Z
dc.date.available2018-03-01T14:12:44Z
dc.date.copyright2017-08-15
dc.date.issued2018-03-01
dc.date.updated2018-03-01T14:12:43Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractAltered permeability of the endothelial barrier in a variety of tissues has implications both in disease pathogenesis and treatment. Glucocorticoids are potent mediators of endothelial permeability and this forms the basis for their heavily-prescribed use as medications to treat ocular disease. However, the effect of glucocorticoids on endothelial barriers elsewhere in the body is less well-studied. Here we investigated glucocorticoid-mediated changes in endothelial flux of Adiponectin (Ad), a hormone with a critical role in diabetes. First, we used monolayers of endothelial cells in vitro and found that the glucocorticoid dexamethasone increased transendothelial electrical resistance and reduced permeability of polyethylene glycol (PEG, molecular weight 4000kDa). Dexamethasone reduced flux of Ad from the apical to basolateral side, measured both by ELISA and Western blotting. We then examined a diabetic rat model induced by treatment with exogenous corticosterone, which was characterized by glucose intolerance and hyperinsulinemia
dc.identifier.urihttp://hdl.handle.net/10315/34409
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subject.keywordsAdiponectin
dc.subject.keywordsCorticosterone
dc.subject.keywordsDiabetes
dc.subject.keywordsEndothelial transport
dc.subject.keywordsGlucocorticoids
dc.subject.keywordsHydraulic conductivity
dc.subject.keywordsParacellular
dc.subject.keywordsTight junctions
dc.titleInvestigate of Changes in Glucose Homeostasis by Modulating Endothelial Permeability
dc.typeElectronic Thesis or Dissertation

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