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Effect of Inflammation on Ketoisocaproic Acid Induced Insulin Resistance In Skeletal Muscle Cells

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dc.contributor.advisorAdegoke, Olasunkanmi A. J.
dc.creatorMann, Gagandeep Singh
dc.date.accessioned2019-03-05T14:56:22Z
dc.date.available2019-03-05T14:56:22Z
dc.date.copyright2018-11-21
dc.date.issued2019-03-05
dc.date.updated2019-03-05T14:56:21Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractBranched-chain amino acids (BCAAs) have displayed metabolic benefits, and play a role in muscle protein synthesis. However, elevated levels of BCAAs and their metabolites have been linked to the pathogenesis of insulin resistance and type 2 diabetes mellitus. It has been demonstrated in my lab that -ketoisocaproic acid (KIC), a metabolite of leucine, inhibited insulin-stimulated glucose uptake, but is converted back to leucine in order to do so. Inflammation, a feature of insulin resistance may modulate the effects of amino acids and their metabolites on insulin action. Thus, I analyzed whether or not there was an additive effect of KIC and inflammation on insulin-stimulated glucose transport in L6 myotubes. Results emphasize previous findings, that even in the presence of inflammation, KIC is converted back to leucine to inhibit insulin-stimulated glucose uptake, suggesting that interventions altering BCAA pathway flux may help in the management/prevention of insulin resistance.
dc.identifier.urihttp://hdl.handle.net/10315/35889
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectCellular biology
dc.subject.keywordsInsulin resistance
dc.subject.keywordsskeletal muscle
dc.subject.keywordsglucose transport
dc.subject.keywordsleucine
dc.subject.keywordsKIC
dc.subject.keywordsmTORC1
dc.subject.keywordsinflammation
dc.subject.keywordsglycogen synthesis
dc.subject.keywordsinsulin signaling
dc.subject.keywordsdiabetes
dc.subject.keywordssiRNA
dc.subject.keywordsBCAAs
dc.subject.keywordsbranched-chain amino acids.
dc.titleEffect of Inflammation on Ketoisocaproic Acid Induced Insulin Resistance In Skeletal Muscle Cells
dc.typeElectronic Thesis or Dissertation

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