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Treatment of Type 1 Diabetic Rats with An SGLT2 Inhibitor: Interactions with Exercise and Hypoglycemia

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dc.contributor.advisorRiddell, Michael C.
dc.creatorGreenberg, Caylee Anna
dc.date.accessioned2019-03-05T14:59:01Z
dc.date.available2019-03-05T14:59:01Z
dc.date.copyright2018-12-14
dc.date.issued2019-03-05
dc.date.updated2019-03-05T14:59:01Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractSodium glucose co-transporter 2 inhibitors (SGLT2i) have begun to show promise as an add-on to insulin therapy in patients with type 1 diabetes (T1D), however the effects of these drugs on plasma glucagon concentrations in T1D are not yet known. We investigated whether 8 days of SGLT2i treatment altered plasma glucagon concentrations in response to voluntary physical activity and insulin-induced hypoglycemia in male and female rats with streptozotocin-induced T1D. SGLT2 inhibition did not alter basal or post-exercise glucagon concentrations and did not affect exercise-associated changes in blood glucose levels. Additionally, SGLT2 inhibition did not affect voluntary running distance. However, in males, SGLT2 inhibition appeared to have suppressed the glucagon response to insulin-induced hypoglycemia (+40.4 48.6 pg/mL vs +22.7 30.8 pg/mL, p=0.02) and decreased the time to taken to reach hypoglycemia (63.8 17.2 min vs 30 13.4 min, p<0.0001). These results have potentially concerning implications for the use of SGLT2i in the treatment of T1D.
dc.identifier.urihttp://hdl.handle.net/10315/35907
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subject.keywordsType 1 diabetes
dc.subject.keywordsSGLT2
dc.subject.keywordsExercise
dc.subject.keywordsHypoglycemia
dc.subject.keywordsBlood glucose
dc.subject.keywordsSGLT2 inhibitor
dc.subject.keywordsRunning wheel
dc.subject.keywordsRodents--Rats
dc.subject.keywordsStreptozotocin
dc.subject.keywordsstz
dc.subject.keywordsInsulin
dc.subject.keywordsGlucagon
dc.titleTreatment of Type 1 Diabetic Rats with An SGLT2 Inhibitor: Interactions with Exercise and Hypoglycemia
dc.typeElectronic Thesis or Dissertation

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