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Gender differences and quality of life in atrial fibrillation: The mediating role of depression

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dc.contributor.authorOng, Lephuong
dc.contributor.authorIrvine, Jane
dc.contributor.authorNolan, Robert
dc.contributor.authorCribbie, Robert
dc.contributor.authorHarris, Louise
dc.contributor.authorNewman, David
dc.contributor.authorMangat, Iqwal
dc.contributor.authorDorian, Paul
dc.date.accessioned2018-06-05T17:24:52Z
dc.date.available2018-06-05T17:24:52Z
dc.date.issued2006
dc.description.abstractObjective This study investigated gender differences, depression, and health-related quality of life (QoL) in a cross-sectional sample of patients with atrial fibrillation (AF). Methods This cross-sectional study involved a convenience sample of AF patients from two tertiary-care clinics in Toronto, Canada. Ninety-three AF patients completed psychometrically validated measures of generic QoL and depression. Mediation analyses evaluated the relationship between gender and QoL using depression as mediating variable. Results Relative to male patients, female patients reported lower physical, but not mental, QoL. Gender was associated with both depression and physical QoL, while depression was correlated with poorer physical QoL. Path analyses demonstrated that depression significantly mediated the relationship between gender and physical QoL. Conclusion Among AF patients, female patients report lower physical QoL relative to male patients, and this relationship may be mediated by self-reported symptoms of depression. Albeit correlational, the findings underscore the need to develop a better understanding of the role of depression in physical QoL, especially when considering the burden of AF in women.en_US
dc.description.sponsorshipSocial Sciences and Humanities Research Council
dc.identifier.citationOng, L., Irvine, J., Nolan, R., Cribbie, R., Harris, L., Newman, D., Mangat, I. & Dorian, P. (2006). Gender differences and quality of life in atrial fibrillation: The mediating role of depression. Journal of Psychosomatic Research, 61, 769-774. doi: 10.1016/j.jpsychores.2006.08.003
dc.identifier.urihttps://doi.org/10.1016/j.jpsychores.2006.08.003en_US
dc.identifier.urihttp://hdl.handle.net/10315/34622
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights.articlehttps://www.jpsychores.com/article/S0022-3999(06)00380-1/fulltext
dc.subjectAtrial fibrillationen_US
dc.subjectDepressionen_US
dc.subjectGenderen_US
dc.subjectQuality of lifeen_US
dc.titleGender differences and quality of life in atrial fibrillation: The mediating role of depression
dc.typeArticleen_US

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