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Regulation of Cyclin G2 Degradation in Human Ovarian Cancer Cells

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dc.contributor.advisorPeng, Chun
dc.creatorKhazai, Shahin
dc.date.accessioned2017-07-27T12:44:09Z
dc.date.available2017-07-27T12:44:09Z
dc.date.copyright2016-11-21
dc.date.issued2017-07-27
dc.date.updated2017-07-27T12:44:08Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractEpithelial ovarian cancer has the highest mortality rate among gynecological malignancies. Uncontrolled cell growth lies at the core of EOC. Normal cell cycle progression is governed by temporal expression of canonical cyclin molecules, which then bind to and activate CDKs. Cyclin G2, an unconventional cyclin, negatively regulates cell cycle and its levels are lowered in various types of cancer. Our lab has previously reported that cyclin G2 is an unstable protein, which is degraded by the UPP. Through a series of in vitro assays, we showed that cyclin G2 is a target of calpains proteolytic activity in a number of human ovarian cancer cells. Furthermore, we found that inhibition of EGFR in those cells led to protection of cyclin G2 from degradation. Finally, we demonstrated that EGF stimulation also resulted in degradation of cyclin G2. Considered together, these findings suggest that activation of EGFR and calpain promote cyclin G2 degradation.
dc.identifier.urihttp://hdl.handle.net/10315/33477
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiochemistry
dc.subject.keywordsCancer
dc.subject.keywordsCell cycle
dc.subject.keywordsCyclin
dc.subject.keywordsCDK
dc.subject.keywordsUnconventional cyclin
dc.subject.keywordsProteolysis
dc.subject.keywordsCalpain
dc.subject.keywordsOvarian cancer
dc.subject.keywordsEpidermal growth factor receptor
dc.titleRegulation of Cyclin G2 Degradation in Human Ovarian Cancer Cells
dc.typeElectronic Thesis or Dissertation

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