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The Association Between Pro-Inflammatory Cytokines and C-Reactive-Protein and the Cognitive and Neurological Outcome in Stroke Survivors: A Systematic Review

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Date

2021-11-15

Authors

Kahnami, Leila

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Abstract

The role of inflammation in neurological prognosis of stroke has been studied previously. However, very little research has thoroughly examined the association between inflammatory markers and neurocognitive outcome post-stroke. Our main goal was to examine the existing literature and this association between inflammatory markers and post-stroke functioning, primarily by examining the tools and methods chosen by researchers to assess neurocognitive outcomes. A systematic literature search retrieved 954 articles to review against inclusion criteria. A total of 21 articles were included in this review. Across the studies, we identified two common themes: 1) lack of research into the diverse stroke populations; and 2) lack of comprehensive neurocognitive measures. Our findings show that research on the area of inflammation and neurocognitive outcome post-stroke has been inconsistent in terms of the methods used, and our conclusions will direct future research exploring the role of inflammatory markers in prediction of cognitive functioning post-stroke.

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Developmental psychology

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