Cardiac remodelling, the reorganization of the heart which occurs in response to factors impacting its function, includes remodelling of the extracellular matrix (ECM) and hypertrophic cardiomyocyte growth. Pressure overload ...

Type 2 diabetes mellitus (T2DM) prevalence continues to increase worldwide. Changes in β-cell function and mechanisms behind the aberrant insulin secretion found in T2DM patients are still poorly understood. Cholesterol ...

Obesity is a key factor contributing to the “metabolic syndrome” which increases the risk for type 2 diabetes, cardiovascular disease and liver complications. In obese conditions, lipotoxicity is a serious concern as the ...

Skeletal muscle insulin resistance is known to play an important role in the pathogenesis of diabetes, however the cellular processes involved are poorly defined. Autophagy, ER stress, the UPR and oxidative stress are being ...

Recent research is aiming to elucidate the molecular mechanisms of metabolic syndrome-associated diseases. This study investigates iron overload-induced adiponectin resistance in cardiovascular disease and diabetes. Iron ...

Altered permeability of the endothelial barrier in a variety of tissues has implications both in disease pathogenesis and treatment. Glucocorticoids are potent mediators of endothelial permeability and this forms the basis ...

Iron overload (IO) is a common yet underappreciated observation in metabolic syndrome (MetS) patients. With the prevalence of MetS continuing to rise, it is of utmost importance to further elucidate mechanisms leading to ...

Unbalanced energy intake over expenditure causes obesity, and the prevalence and incidences of obesity have increased over last decades. People with obesity have a cluster of metabolic co-morbidities called metabolic ...