Browsing Biology by Title
Now showing items 74-93 of 143
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Optimizing NECEEM-Based Aptamer Selection Using Emulsion PCR To Obtain Potential DNA Inhibitors For The Human Dealkylating Enzyme ABH2
(2015-08-28)The oldest chemotherapeutic drugs still in use today are the alkylating agents. In many cases, their effectiveness is hindered by the ability of cancerous cells to develop resistance using the cell’s innate DNA repair ... -
Peripheral and Central Auditory Processing in People With Absolute Pitch
(2016-11-25)Absolute pitch (AP) is a rare ability that is defined by being able to name musical pitches without a reference standard. This ability has been of interest to researchers studying music cognition and the processing of ... -
Phylogeny of Chilicola (Hylaeosoma)(Hymenoptera:Colletidae) Based on Morphological and Morphometric Data of Extant and Fossil Species, with Description of Seven New Species
(2018-05-28)Combined data approach is used to establish a phylogeny of the bee subgenus Chilicola (Hylaeosoma) Ashmead 1898 (Colletidae: Xeromelissinae). Results of phylogenetic analyses are presented, based upon 92 morphological ... -
Polar Bear (Ursus Maritimus) Foraging Ecology in the Western Canadian Arctic
(2018-05-28)Climate change has led to abrupt declines in sea ice over the past three decades. Polar bears (Ursus maritimus) rely on sea ice as their primary habitat to hunt marine mammal prey. Due to their position at the top of the ... -
Polar Bear (Ursus Maritimus) Foraging Ecology in Western Hudson Bay
(2018-05-28)The ecological response of climate change is expected to be especially pronounced across the circumpolar Arctic. Predicted declines in sea ice extent and seasonal duration are expected to affect the foraging ecology of ... -
Pollinator-Mediated Interactions of Foundation Plants in the Mojave Desert
(2019-03-05)Pollination facilitation is an indirect interaction whereby one plant species positively influences the reproductive success of another plant species through pollinators. First, we conducted a systematic review of the ... -
Population Genomic Approaches to Understanding the Genetics and Evolution of Social Insects
(2017-07-27)Eusocial animals are comprised of distinct and specialized individuals that carry out specific tasks within colonies. Despite decades of research on eusocial insects (e.g. bees, wasps, termites, and ants), we lack knowledge ... -
Population Genomics of Polistes Wasps
(2017-07-27)The molecular mechanisms influencing the evolution of social behaviour in insects are of great interest and have been the focus of many recent studies. Chapter one of this thesis reviews several major hypotheses regarding ... -
Possible Roles for Tropomyosin During Anaphase Chromosome Movement
(2018-03-01)During anaphase, chromosomes move toward the spindle poles by forces transmitted through their kinetochore fibres. The fibres contain microtubules, as well as actin and myosin, which work together to produce the force that ... -
Proteomic Analysis of Core Histones and Their Variants in Tetrahymena Thermophila
(2015-12-16)Several histone chaperones including Nasp, Asf1, Caf1 and Hira have been identified to function in the transport and assembly of newly synthesized histones. To characterize histone transport machinery and chromatin ... -
Regulation and Function of MEF2 in Cardiomyocytes
(2018-11-21)Regular formation of the mammalian heart needs precise spatial and temporal transcriptional regulation of gene programs in ardiomyocytes. Cardiac transcription factors are defined, in this context, as essential transcriptional ... -
Regulation of Cardiac Gene Expression by B-adrenergic Signaling and Heart Failure
(2017-07-27)Cardiac diseases such as coronary artery disease are the major causes of death around the world. Regulation of -adrenergic receptors by catecholamines is an important facet of understanding cardiac function in health and ... -
Regulation of Cardiac Remodelling by Adiponectin in Response to Pressure Overload and Unloading: A Focus on the Extracellular Matrix
(2015-08-28)Cardiac remodelling, the reorganization of the heart which occurs in response to factors impacting its function, includes remodelling of the extracellular matrix (ECM) and hypertrophic cardiomyocyte growth. Pressure overload ... -
Regulation of Cyclin G2 Degradation in Human Ovarian Cancer Cells
(2017-07-27)Epithelial ovarian cancer has the highest mortality rate among gynecological malignancies. Uncontrolled cell growth lies at the core of EOC. Normal cell cycle progression is governed by temporal expression of canonical ... -
Reinforcement Learning Describes the Computational and Neural Processes Underlying Flexible Learning of Values and Attentional Selection
(2015-12-16)Attention and learning are cognitive control processes that are closely related. This thesis investigates this inter-relatedness by using computational models to describe the mechanisms that are shared between these ... -
Revealing the Distribution of Ion Transport Peptide and the Function of its Prospective Second Messengers on the Hindgut of the Adult Mosquito, Aedes aegypti
(2018-03-01)The insect excretory system includes the Malpighian tubules and hindgut, and plays a vital role in maintaining hydromineral balance of the haemolymph. Unfortunately, ion and water transport mechanisms in the hindgut of ... -
RNA Chaperone Activity of the RRM2 Domain of Human La
(2015-12-16)Genuine La proteins are abundant RNA binding factors that primarily facilitate maturation of nascent precursor RNAs in eukaryotes. Chaperone activity is a conserved feature in the La superfamily, yet the structural basis ... -
Role and Regulation of FRA-2 During Skeletal Muscle Development
(2015-01-26)Regulation of skeletal muscle development and regeneration is critical to all metazoans and also of clinical relevance as muscle wasting is manifested in a variety of disorders. The events contributing to development and ... -
Role of a SET/Smad7 Interaction in Skeletal Myogenesis
(2017-07-26)A look at the interaction between the histone chaperone SET/TAF-I and the TGF signalling inhibitor Smad7 in the context of skeletal muscle differentiation. Here we report that SET can function as an inhibitor of transcription ... -
Role of SNARE Proteins in Natriuretic Peptide Secretion by the Heart
(2015-01-26)The hormones atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are stored and secreted by cardiac myocytes. To date, there is little information reported regarding the cellular mechanisms regulating the ...