Chemistry
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Development of New and Modification of Existing Methods for the Primary Screening of Aptamers and Antibodies by Means of Capillary Electrophoresis
(2021-03-08)Discovery of new drugs starts with screening a library of drug candidates (ligands) for their ability to bind targets. Such a screening can be conducted by a variety of analytical techniques; however, Capillary Electrophoresis ... -
Palladium-Catalyzed Functionalization of 4-Alkylpyridines: Pyridlyic Dehydrogenation & Mechanistic Investigation of Pyridylic Allylation
(2021-03-08)Pyridines are important frameworks in drug development, valued for their ubiquitous presence in biologically active compounds. As such, we have taken a keen interest in developing mild methods for pyridylic functionalization ... -
Chemical Profiling of Drugs and Metabolites from Complex Biological Matrices by Atmospheric Pressure and Ambient Ionization Mass Spectrometry
(2020-11-13)Atmospheric pressure and ambient mass spectrometry (MS) techniques are powerful analytical tools for the omics technologies. Ambient MS techniques allow for the surface analysis of molecules directly from substrates and ... -
Hamiltonian Formalism of Spin-Orbit Jahn-Teller and Pseudo-Jahn-Teller Problems in Trigonal and Tetragonal Symmetries
(2020-11-13)A formalism for expansions of all bimodal spinorbit JahnTeller and pseudo-JahnTeller Hamiltonian operators in trigonal and tetragonal symmetries is presented. With the formalism, we can easily obtain expansion formulas of ... -
Optimizing the Toehold-Mediated Strand Displacement Reaction on the Nanoparticle Surface by Altering the Surface DNA Density for the Design of a microRNA NanoOptical Sensor
(2020-11-13)We present a method for modulating the kinetics and thermodynamic properties of aggregation and disassembly processes of DNA-functionalized nanoparticles. Specifically, we examine factors influencing the toehold ... -
Thermodynamic Analysis of Aptamer-Ligand Binding by Isothermal Titration Calorimetry
(2020-08-11)Aptamers are short, single stranded nucleic acid molecules typically 15 to 60 nucleotides in length with the capacity of binding diverse molecular targets, ranging from small molecules to whole cells primarily due to their ... -
Structural Mass Spectrometry Analysis of RNA Chaperones and Protein Therapeutics
(2020-08-11)Since the advent of soft ionization techniques, most notably electrospray ionization (ESI), the application of mass spectrometry (MS) analysis has expanded to intact biomolecules. ESI-MS gave rise to the field of structural ... -
Mild and Selective Palladium-Catalyzed Pyridylic Allylation of 4-Alkylpyridines
(2020-08-11)Pyridines and related heterocycles enjoy widespread occurrence in biologically relevant natural products and drug-like molecules. Therefore, new methods that facilitate their synthesis and incorporation into drug-like ... -
Synthesis of New Titanium Complexes Bearing a Bidentate Monoanionic Inversely-Polarized Phosphaalkene-Enolate Ligand and their Activity in Olefin Polymerization
(2020-05-11)The synthesis and characterization of several inversely-polarized phosphaalkenes, including the first ring-expanded inversely-polarized hydrido-phosphaalkene and imidazolidine-based inversely-polarized phosphaalkene-enolate ... -
Performance of Nanostructured Ternary Metal Spinel Oxides as Efficient Electrocatalysts
(2020-05-11)In this work, various spinel oxides, namely Ni1-xCuxCo2O4 (0 x 0.75), Fey(Ni/Cu)x-y Co3-xO4 [(0.5 x 1), (0.1 y 0.15)] have been prepared on Fluorine coated Tin Oxide (FTO) glass by the thermal decomposition method. ... -
Novel Olefin Polymerization Pre-Catalyst Bearing an Inversely-Polarized Phosphaalkene Ethenolate Monoanionic Bidentate Ligand and its Polymerization Studies
(2020-05-11)The synthesis and structure elucidation of the first monoanionic bidentate ligand bearing an inversely-polarized phosphaalkene, its precursors and the first titanium complex bearing such ligand are herein reported. ... -
The Total Synthesis of () 7-HDHA
(2020-05-11)Fatty acid () 7-HDHA was recently identified as an endogenous ligand for PPAR/ receptors by one of our collaborators Dr. Henry Krause group. While this discovery is promising in understanding PPARs mechanism of effects and ... -
Characterizing Conformational Dynamics and Catalytic Activity of Enzymes by Hydrogen-Deuterium Exchange Mass Spectrometry
(2019-11-22)Determining the conformational dynamics of enzymes as they undergo catalysis has been challenging for decades due to the short timescale and limitations of traditional analysis, including techniques such as CPMG 2D NMR and ... -
Using PNA Probes for Hybridization-Based Analysis of miRNAs in Capillary Electrophoresis
(2019-11-22)The inherent separation inefficiencies of the excess probes and hybrids and the hybrids from each other limits the use of capillary electrophoresis (CE) for hybridization-based analysis of microRNA (miRNAs). Our lab developed ... -
Characterization, Imaging and Quantitation of Small Molecules by Ambient Ionization Mass Spectrometry
(2019-11-22)For more than a century mass spectrometry has been a well-known technique in the field of chemical analytics. Its selectivity and sensitivity has made it popular in various fields. From analysis of pure organics, its use ... -
Mass Spectrometry Methods for Enhanced Characterization of Biological Systems
(2019-07-02)As the pharmaceutical industry moves towards larger protein-based therapeutics over chemically synthesized small molecules, there are increasing demands for parallel advancement in the technologies used for quality control ... -
Characterizing the Structure-Function Relationship of Pathological Proteins
(2019-07-02)Protein structure and dynamics dictate the fundamentals of protein function. For example, a structured protein must change its conformation when interacting with various ligands. In addition, misfolded or intrinsically ... -
Comparing Solution-Phase and Gas-Phase Protein Stability Using Ion Mobility and Differential Mobility Mass Spectrometry
(2019-07-02)A critical quality attribute for many proteins concerning biopharmaceutical products is the proteins stability. Current stability assays are lengthy but some quick stability assays to determine the proteins melting temperature ... -
Iron-Doped Titanium Dioxide Nanomaterials: Synthesis, Characterization and Photodegradation Catalytic Behavior
(2019-07-02)Titanium dioxide (TiO2) is a very good material for various photocatalytic industrial applications because of its non-toxicity, high chemical stability, low cost and relatively good photoactivity. However, one of the most ... -
The Measurement of Atmospheric Species with Absorptions Close to the Actinic Flux Cut-Off by Active & MAX-DOAS: Chlorine Monoxide (CIO) & Sulphur Dioxide (SO2)
(2019-07-02)The gas-phase chlorine monoxide (ClO) radical has been studied extensively for its role in catalytic stratospheric ozone depletion following the discovery of the Antarctic ozone hole in 1985. Reactive chlorine chemistry ...
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