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Characterization of Structures and Dynamics of Intrinsically Disordered Domain and Proteins Using Time Resolved-Hydrogen Deuterium Exchange Mass Spectrometry
Proteins are inherently dynamic. Virtually all of the processes that underlie biological activity, including binding partner recognition, catalysis and allostery among many others, require transient adoption of specific ...
Structural and Functional Studies of TraG From the F Plasmid and the Major Pilin From Coxiella Burnetii
The Escherichia coli F-plasmid houses all genes necessary for the assembly of its conjugative machinery to facilitate successful DNA transfer. TraG is one of the largest proteins (102 kDa) encoded in the transfer (tra) ...
Synthesis of Primary Arylamines Using Bulky Palladium N-heterocyclic Carbene Precatalysts
The reaction between aryl halides and ammonia was investigated using N-heterocyclic carbene (NHC) ligated palladium pre-catalysts. The use of NHCs is well documented for coupling of alkyl and arylamines, but there is little ...