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Novel Kinetic Solution-Based Separation Approaches for Small Molecule Drug Discovery
(2017-07-27)
The modern pharmaceutical industry has achieved remarkable successes in medicinal chemistry. However, many diseases are incurable due to the difficulty of finding new drugs. De novo drug discovery contains two steps: the ...
Surface and Interfacial Approaches for the Characterization of Biomolecular Interactions and to Optimize Desi-MS Performance
(2016-11-25)
This work involves the surface and interfacial characterization of biomolecular interactions by atomic force microscopy and optimization of desorption electrospray ionization mass spectrometry. In the first part (part I), ...
Part One: A Flow Reactor With In-Line Analytics: Design and Implementation Part Two: In-Line Derivatization of Protic Compounds for GC/MS Reaction Monitoring
(2016-11-25)
The creation of an automated synthetic reaction system with in-line analytics is presented in two parts. First, the design and implementation of a flow reactor system complete with in-line gas chromatography mass spectrometry ...
Characterization of Structures and Dynamics of Intrinsically Disordered Domain and Proteins Using Time Resolved-Hydrogen Deuterium Exchange Mass Spectrometry
(2017-07-27)
Proteins are inherently dynamic. Virtually all of the processes that underlie biological activity, including binding partner recognition, catalysis and allostery among many others, require transient adoption of specific ...
Studies of Protein Function by Liquid Chromatography-Mass Spectrometry
(2015-01-26)
Complete genomes of many organisms have been recorded using high throughput nucleic acid sequencing; however the intricate functions of the gene products remain largely undiscovered. As the most prominent technology for ...
Evaluating the Utility of an Atmospheric Pressure Chemical Ionization Mass Spectrometer for Detecting Organic Peroxides During Beta-Pinene Ozonolysis Experiments
(2015-08-28)
The intent of this study was to use a positive-ion atmospheric pressure chemical ionization mass spectrometer ((+) APCI-MS/MS) to detect organic peroxide products formed during β-pinene ozonolysis experiments. Detection ...
Ambient Ionization: Surface Analysis of Sexual Assault Evidence and 2-Dimensional Imaging of Whole-Body Zebra Fish (Danio Rerio) Using Desorption Electrospray Ionization
(2015-08-28)
Desorption electrospray ionization (DESI) is an ambient surface analysis technique capable of producing 2D and 3D images. The ionization mechanism utilizes a pneumatically assisted sprayer to deposit a charged solvent onto ...
A Comparative Study Performed on Two Ambient Ionization Techniques: Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) and Easy Ambient Sonic Spray Ionization Mass Spectrometry (EASI-MS)
(2015-08-28)
Main project of my master’s thesis involved comparison between two sister methods: desorption electrospray ionization mass spectrometry (DESI−MS) and easy ambient ionization mass spectrometry (EASI−MS). These methods are ...
Chemical and Physical Studies of Secondary Organic Aerosol Formed from Beta-pinene Photooxidation
(2017-07-27)
Atmospheric organic aerosols have a significant impact on climate and human health. However, our understanding of the physical and chemical properties of these aerosols is inadequate, thus their climate and health influences ...
Mass Spectrometry Methods for Enhanced Characterization of Biological Systems
(2019-07-02)
As the pharmaceutical industry moves towards larger protein-based therapeutics over chemically synthesized small molecules, there are increasing demands for parallel advancement in the technologies used for quality control ...