Collision-induced dissociation spectra of protonated peptides [(aminoacid)n + H]+ form, after the loss of water, nominal [bn]+ ions which are dependent on both peptide length and amino acid sequence. Protonated tetraglycine ...

Proteins are inherently dynamic. Virtually all of the processes that underlie biological activity, including binding partner recognition, catalysis and allostery among many others, require transient adoption of specific ...

The modern pharmaceutical industry has achieved remarkable successes in medicinal chemistry. However, many diseases are incurable due to the difficulty of finding new drugs. De novo drug discovery contains two steps: the ...

Desorption electrospray ionization (DESI) is an ambient surface analysis technique capable of producing 2D and 3D images. The ionization mechanism utilizes a pneumatically assisted sprayer to deposit a charged solvent onto ...

Atmospheric organic aerosols have a significant impact on climate and human health. However, our understanding of the physical and chemical properties of these aerosols is inadequate, thus their climate and health influences ...

The intent of this study was to use a positive-ion atmospheric pressure chemical ionization mass spectrometer ((+) APCI-MS/MS) to detect organic peroxide products formed during β-pinene ozonolysis experiments. Detection ...

Complete genomes of many organisms have been recorded using high throughput nucleic acid sequencing; however the intricate functions of the gene products remain largely undiscovered. As the most prominent technology for ...

This work involves the surface and interfacial characterization of biomolecular interactions by atomic force microscopy and optimization of desorption electrospray ionization mass spectrometry. In the first part (part I), ...

As the pharmaceutical industry moves towards larger protein-based therapeutics over chemically synthesized small molecules, there are increasing demands for parallel advancement in the technologies used for quality control ...

Main project of my master’s thesis involved comparison between two sister methods: desorption electrospray ionization mass spectrometry (DESI−MS) and easy ambient ionization mass spectrometry (EASI−MS). These methods are ...