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Synthesis, Characterization and Reactivity Study of Bis (Imino)-N-Heterocyclic Carbene Transition Metal Complexes
(2015-08-28)
Three generations of the first 1,3-bis(imino) N-heterocyclic carbene (NHC) ligand precursors were synthesized, isolated and characterized. The synthetic methodologies of the ligand precursors were controlled by the iminic ...
Biomedical Characterization of the WalKR and the LytSR Two Component System From Staphylococcus Aureus
(2015-08-28)
Staphylococcus aureus is a major gram-positive pathogen, because of its remarkable capacity to develop resistance against different antimicrobial agents. It has been shown that in S. aureus two component systems (TCS) ...
Development of Microfluidic Devices for Studying Protein Conformational Dynamics via HDX/TRESI-MS
(2014-07-28)
Studies of protein conformational dynamics can lead to a deeper understanding of biological functions of proteins, protein/protein interactions, catalysis and allostery. Most of the conformers involved in biological pathways ...
Collison-Induced Dissociation of 4-imidazolone Ions; Isomers of [bn]+ Derived from Peptides After Water Loss
(2018-08-27)
Collision-induced dissociation spectra of protonated peptides [(aminoacid)n + H]+ form, after the loss of water, nominal [bn]+ ions which are dependent on both peptide length and amino acid sequence. Protonated tetraglycine ...
Characterization of Structures and Dynamics of Intrinsically Disordered Domain and Proteins Using Time Resolved-Hydrogen Deuterium Exchange Mass Spectrometry
(2017-07-27)
Proteins are inherently dynamic. Virtually all of the processes that underlie biological activity, including binding partner recognition, catalysis and allostery among many others, require transient adoption of specific ...
Part I: Mechanistic Insight in Alkyl-Alkyl and Aryl-Aryl Negishi Cross-Coupling Part II: Large Scale Synthesis of NHC Precursors: 2,6-DI(3-Pentyl) Aniline and 2,6-DI (4-Heptyl) Aniline
(2016-09-20)
Part I: An efficient method for alkyl-alkyl Negishi cross-coupling reaction of unactivated primary alkyl halides with higher-order zincate species (synthesized from dialkylzinc and a non-coordinating halide salt in situ) ...
Measuring the Dynamics and Kinetics of OXA-58, a Class D Abeta-Lactamase from Acinetobacter Baumannii
(2015-12-16)
OXA-58 is a β-lactamase enzyme that bacteria Acinetobacter baumannii employ as their chief defense mechanism against β-lactam antibiotic treatment. The catalytic activity of OXA-58 and its mutants was monitored as they ...
Bio-Orthogonal Manipulation of Cellular Membranes for Biological Applications
(2018-05-28)
Recent breakthroughs using novel chemistry and nanotechnology methodologies for cellular biology applications have spurred tremendous interest in the development of new technologies to manipulate cell-lines or cellular ...
Probing Charge Generation in 3D Photonic Poly(3-hexylthiophene)/Titanium Dioxide Nanocomposites for Bulk Heterojunction Solar Cells
(2016-09-20)
Organic photovoltaics (OPVs) are attractive for their inexpensiveness, large-scale fabrication methods, flexibility and semi-transparency. OPVs have lower efficiencies than conventional inorganic semiconductor-based solar ...
Aryl-Substituted Imino-N-Heterocyclic Carbene Complexes Of Late Transition Metals: Synthesis and Reactivity Studies
(2015-01-26)
N-heterocyclic carbenes (NHCs) have found enormous success as ancillary ligands in catalysts in many areas of organometallic chemistry. Surprisingly, their use in olefin polymerization, until recently, was not widely ...