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Unravelling the Conformational Dynamics of a-Synuclein's Folding Pathway By Hydrogen-Deuterium Exchange Mass Spectrometry in the Presence of Phospholipid Nanodiscs
(2019-03-05)
Conformational changes of the -synuclein protein during docking into a phospholipid membrane is suspected to play a central role in neuronal cell death during Parkinsons disease. This intrinsically disordered protein obtains ...
Characterization of Structures and Dynamics of Intrinsically Disordered Domain and Proteins Using Time Resolved-Hydrogen Deuterium Exchange Mass Spectrometry
(2017-07-27)
Proteins are inherently dynamic. Virtually all of the processes that underlie biological activity, including binding partner recognition, catalysis and allostery among many others, require transient adoption of specific ...
Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation
(2019-03-05)
Continuous microfluidic technology has proven to be a potential competitor with established batch systems for facilitating chemical synthesis and purification, and more amenable to miniaturization, integration, and automation. ...
Part I: Mechanistic Insight in Alkyl-Alkyl and Aryl-Aryl Negishi Cross-Coupling Part II: Large Scale Synthesis of NHC Precursors: 2,6-DI(3-Pentyl) Aniline and 2,6-DI (4-Heptyl) Aniline
(2016-09-20)
Part I: An efficient method for alkyl-alkyl Negishi cross-coupling reaction of unactivated primary alkyl halides with higher-order zincate species (synthesized from dialkylzinc and a non-coordinating halide salt in situ) ...
Synthesis and Reactivity of Umpolung Reagents Through Transition Metal Catalysis
(2019-03-05)
The cyclopropanol-derived palladium-homoenolates have previously been exploited as a unique class of cross-coupling partners in our group. The major advantage of using cyclopropanols as the cross-coupling partners is the ...
Nanostructured Mixed Transition Metal Spinel Oxide as Efficient Electrocatalysts
(2016-09-20)
CuxCo3-xO4 films with x values ranging from 0 to 1 have prepared in order to optimize their electrocatalytic properties for the oxygen evolution reaction (OER). Two methods have been used for the preparation of CuxCo3-xO4, ...
The Cocaine-Binding Aptamer: A Thermodynamic and Structural Overview of Specific and Non-Specific Binding Interactions
(2016-09-20)
Isothermal Titration Calorimetry (ITC) studies were conducted wherein variances in the heat capacity of binding (Cp) among variants of the cocaine-binding aptamer were suggestive of two distinct binding mechanisms. Aptamer ...
Probing Charge Generation in 3D Photonic Poly(3-hexylthiophene)/Titanium Dioxide Nanocomposites for Bulk Heterojunction Solar Cells
(2016-09-20)
Organic photovoltaics (OPVs) are attractive for their inexpensiveness, large-scale fabrication methods, flexibility and semi-transparency. OPVs have lower efficiencies than conventional inorganic semiconductor-based solar ...
Palladium Mediated Synthesis of Substituted Phenols From Acyclic Ketones
(2016-09-20)
The direct functionalization of phenols at the ortho and para position is generally facilitated by the electron-donating nature of the hydroxyl group. Accessing meta substituted phenols, on the other hand, often requires ...
Synthesis, Characterization and Reactivity Study of Bis (Imino)-N-Heterocyclic Carbene Transition Metal Complexes
(2015-08-28)
Three generations of the first 1,3-bis(imino) N-heterocyclic carbene (NHC) ligand precursors were synthesized, isolated and characterized. The synthetic methodologies of the ligand precursors were controlled by the iminic ...