Multi-dimensional HPLC techniques enable researchers to monitor multiple essential and sometimes, critical quality attributes (CQAs) in parallel. A unique three-column, four-dimension liquid chromatography system employing ...

Within a host, pathogenic bacteria employ several mechanisms that enhance their survival and motility. These mechanisms include their ability to adhere, replicate (in order to avoid eradication), and secretion of virulent ...

Tissue engineering is a growing field of science that relies on the use of material chemistry, engineering, genetics, and cell biology to produce functional tissues for use in transplantation, drug testing and disease ...

The first part of this research focuses on developing efficient methods to address challenging Buchwald Hartwig amination reactions using Pd-NHC pre-catalysts. Specifically, we focused on: a) coupling of sterically hindered ...

Collision-induced dissociation spectra of protonated peptides [(aminoacid)n + H]+ form, after the loss of water, nominal [bn]+ ions which are dependent on both peptide length and amino acid sequence. Protonated tetraglycine ...

In this thesis, we examined the CID spectra of the closed-shell [A4W-Me oxa + H]+ ions, which are completely identical, and indicates sequence scrambling. There are some unique fragmentation patterns from this set of ions ...

Emission of CH4 from landfills in Canada are not well constrained and in Ontario constitute the largest point source emitters. The purpose of this study was to develop and test a ground based method for quantifying CH4 ...

This thesis presents the work to study and expand the coordination chemistry of bis(amido)pyridine to ruthenium and cobalt. Chapter 1 presents the properties, the coordination chemistry and the synthesis of the bis(amido)pyridine ...

This research work examines the dissociation chemistry of tripositive complexes formed by trivalent lanthanide ions and small peptides with tandem mass spectrometry under low-energy collision-induced dissociation (CID). ...

We have developed a two-step synthesis of meta-substituted phenols in one pot, in good to excellent yield. A Pd2+ source is the catalyst for both steps of the synthesis, which includes a cross-coupling reaction between ...