Now showing items 1-6 of 6
Novel Kinetic Solution-Based Separation Approaches for Small Molecule Drug Discovery
The modern pharmaceutical industry has achieved remarkable successes in medicinal chemistry. However, many diseases are incurable due to the difficulty of finding new drugs. De novo drug discovery contains two steps: the ...
Structure-Function Studies of Scaffolding Proteins Involved in the Formation of Neuronal Connections: AIDA1 and CASKIN2
Modular proteins serve assembly platforms and often actively regulate cellular signaling events. An intrinsic diversity of interaction modules, typical for scaffolding proteins, facilitates the organization of numerous ...
Structural and Functional Studies of TraG From the F Plasmid and the Major Pilin From Coxiella Burnetii
The Escherichia coli F-plasmid houses all genes necessary for the assembly of its conjugative machinery to facilitate successful DNA transfer. TraG is one of the largest proteins (102 kDa) encoded in the transfer (tra) ...
Chemical and Physical Studies of Secondary Organic Aerosol Formed from Beta-pinene Photooxidation
Atmospheric organic aerosols have a significant impact on climate and human health. However, our understanding of the physical and chemical properties of these aerosols is inadequate, thus their climate and health influences ...
Synthesis of Primary Arylamines Using Bulky Palladium N-heterocyclic Carbene Precatalysts
The reaction between aryl halides and ammonia was investigated using N-heterocyclic carbene (NHC) ligated palladium pre-catalysts. The use of NHCs is well documented for coupling of alkyl and arylamines, but there is little ...
Characterization of Structures and Dynamics of Intrinsically Disordered Domain and Proteins Using Time Resolved-Hydrogen Deuterium Exchange Mass Spectrometry
Proteins are inherently dynamic. Virtually all of the processes that underlie biological activity, including binding partner recognition, catalysis and allostery among many others, require transient adoption of specific ...