Browsing Chemistry by Title
Now showing items 1-20 of 75
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A Comparative Study Performed on Two Ambient Ionization Techniques: Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) and Easy Ambient Sonic Spray Ionization Mass Spectrometry (EASI-MS)
(2015-08-28)Main project of my master’s thesis involved comparison between two sister methods: desorption electrospray ionization mass spectrometry (DESI−MS) and easy ambient ionization mass spectrometry (EASI−MS). These methods are ... -
A Desorption Electrospray Ionization Mass Spectrometry Imaging Approach to Monitor Toxic Ionic Liquids in Zebrafish (Danio Rerio)
(2016-11-25)Ambient mass spectrometry imaging has become an increasingly powerful technique for the direct analysis of biological tissues in the open environment with minimal sample preparation and fast analyses times. In this study, ... -
A Novel Ground Based Mass-Balance Method for Methane Emission Quantification
(2018-08-27)Emission of CH4 from landfills in Canada are not well constrained and in Ontario constitute the largest point source emitters. The purpose of this study was to develop and test a ground based method for quantifying CH4 ... -
A Stable Dicationic Salt in Reactive DESI-MS Imaging in Positive Ion Mode to Analyze Biological Samples
(2015-12-16)A dicationic salt was applied for imaging in reactive desorption electrospray ionization mass spectrometry (DESI-MS) on biological samples. The samples interrogated in this experiment were whole body zebrafish tissues and ... -
A Study of Bis (Amido) Pyridine Coordination Chemistry to Ruthenium and Cobalt Metals
(2018-08-27)This thesis presents the work to study and expand the coordination chemistry of bis(amido)pyridine to ruthenium and cobalt. Chapter 1 presents the properties, the coordination chemistry and the synthesis of the bis(amido)pyridine ... -
Adsorption and Self-assembly of Proteins at Chemically Modified Surfaces
(2015-08-28)Our research is mostly focused on the subject of adsorption and self-assembly of proteins at modified surfaces. We employed atomic force microscopy (AFM) to study bovine serum albumin (BSA) and insulin adsorption at 1-decene- ... -
Ambient Ionization: Surface Analysis of Sexual Assault Evidence and 2-Dimensional Imaging of Whole-Body Zebra Fish (Danio Rerio) Using Desorption Electrospray Ionization
(2015-08-28)Desorption electrospray ionization (DESI) is an ambient surface analysis technique capable of producing 2D and 3D images. The ionization mechanism utilizes a pneumatically assisted sprayer to deposit a charged solvent onto ... -
Application of Pd-NHC Complexes in Challenging Amination Reactions
(2019-07-02)Among Pd-catalyzed carbon-heteroatom cross-coupling reactions, C-N bond formation, known as Buchwald-Hartwig amination (BHA), is by far the most studied reaction owing to the prevalence of arylated amines in pharmaceuticals, ... -
Aryl-Substituted Imino-N-Heterocyclic Carbene Complexes Of Late Transition Metals: Synthesis and Reactivity Studies
(2015-01-26)N-heterocyclic carbenes (NHCs) have found enormous success as ancillary ligands in catalysts in many areas of organometallic chemistry. Surprisingly, their use in olefin polymerization, until recently, was not widely ... -
Bio-Orthogonal Manipulation of Cellular Membranes for Biological Applications
(2018-05-28)Recent breakthroughs using novel chemistry and nanotechnology methodologies for cellular biology applications have spurred tremendous interest in the development of new technologies to manipulate cell-lines or cellular ... -
Biomedical Characterization of the WalKR and the LytSR Two Component System From Staphylococcus Aureus
(2015-08-28)Staphylococcus aureus is a major gram-positive pathogen, because of its remarkable capacity to develop resistance against different antimicrobial agents. It has been shown that in S. aureus two component systems (TCS) ... -
Characterization of Function and Role of FMTA in Staphylococcus Aureus
(2015-08-28)Staphylococcus aureus is one of the major reasons for infectious mortality and morbidity. Due to extensive use of antibiotics, S. aureus has acquired resistance to almost all antibiotics. FmtA is one of the additional ... -
Characterization of Structures and Dynamics of Intrinsically Disordered Domain and Proteins Using Time Resolved-Hydrogen Deuterium Exchange Mass Spectrometry
(2017-07-27)Proteins are inherently dynamic. Virtually all of the processes that underlie biological activity, including binding partner recognition, catalysis and allostery among many others, require transient adoption of specific ... -
Characterizing Protein Dynamics of Protein-Ligand Interactions by Hydrogen-Deuterium Exchange Mass Spectrometry
(2015-01-26)The study of protein-ligand and protein-protein interactions is of paramount importance to the understanding of their biological function. Whereas this area of research has been largely dominated by conventional structural ... -
Characterizing the Structure-Function Relationship of Pathological Proteins
(2019-07-02)Protein structure and dynamics dictate the fundamentals of protein function. For example, a structured protein must change its conformation when interacting with various ligands. In addition, misfolded or intrinsically ... -
Charge Transfer in Poly (3-Hexylthiophene) / Titanium Dioxide Inverse Opals: Effects of Surface Passivation and Donor Concentration
(2019-07-02)Hybrid photovoltaics are attractive because of their low cost and ability to be applied onto flexible substrates. However defect states can trap charges and are undesirable. We investigate TiO2 inverse opals treated with ... -
Chemical and Physical Studies of Secondary Organic Aerosol Formed from Beta-pinene Photooxidation
(2017-07-27)Atmospheric organic aerosols have a significant impact on climate and human health. However, our understanding of the physical and chemical properties of these aerosols is inadequate, thus their climate and health influences ... -
Collison-Induced Dissociation of 4-imidazolone Ions; Isomers of [bn]+ Derived from Peptides After Water Loss
(2018-08-27)Collision-induced dissociation spectra of protonated peptides [(aminoacid)n + H]+ form, after the loss of water, nominal [bn]+ ions which are dependent on both peptide length and amino acid sequence. Protonated tetraglycine ... -
Comparing Solution-Phase and Gas-Phase Protein Stability Using Ion Mobility and Differential Mobility Mass Spectrometry
(2019-07-02)A critical quality attribute for many proteins concerning biopharmaceutical products is the proteins stability. Current stability assays are lengthy but some quick stability assays to determine the proteins melting temperature ... -
Designing a Scaffold-Free Bio-Orthogonal Click Chemistry Method of Cell Assembly for Application in Tissue Engineering
(2018-03-01)Tissue engineering is a growing field of science that relies on the use of material chemistry, engineering, genetics, and cell biology to produce functional tissues for use in transplantation, drug testing and disease ...