Browsing Chemistry by Issue Date
Now showing items 21-40 of 88
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Ambient Ionization: Surface Analysis of Sexual Assault Evidence and 2-Dimensional Imaging of Whole-Body Zebra Fish (Danio Rerio) Using Desorption Electrospray Ionization
(2015-08-28)Desorption electrospray ionization (DESI) is an ambient surface analysis technique capable of producing 2D and 3D images. The ionization mechanism utilizes a pneumatically assisted sprayer to deposit a charged solvent onto ... -
Synthesis and Characterization of Organic Ligands and the Corresponding Ru Dyes for Dye-Sensitized Solar Cells
(2015-08-28)Ru(II) complexes have been of great interest as dyes for Dye-Sensitized Solar Cells (DSSCs), where they absorb solar energy and inject an electron into the conduction band of a semiconductor to start the process. The ... -
Palladium (II) Mediated Transformation: Exploring Synthetic Methodology for the Synthesis of Cyclopentenones from Tertiary-Cyclobutanois
(2015-08-28)A new method for the synthesis of ring-fused cyclopentenone is described. The method utilizes the built-in strain of tertiary cyclobutanol to drive the palladium(II)-catalyzed rearrangement to the corresponding ring-fused ... -
A Stable Dicationic Salt in Reactive DESI-MS Imaging in Positive Ion Mode to Analyze Biological Samples
(2015-12-16)A dicationic salt was applied for imaging in reactive desorption electrospray ionization mass spectrometry (DESI-MS) on biological samples. The samples interrogated in this experiment were whole body zebrafish tissues and ... -
Obtaining Structural Insights on Bacterial Protein Complexes Using Time-Resolved Hydrogen-Deuterium Exchange Mass Spectrometry
(2015-12-16)Persistent infections by Pseudomonas aeruginosa are initiated by interaction of a type IV pilus (T4P) with receptors on the mucosal cells of susceptible hosts. Here, we examine the structural changes occurring between the ... -
Synthesis and Reactivity Studies of Square Pyramidal Complexes on Group 5 and 6 Metals for Nitrogen and Small Molecule Fixation
(2015-12-16)I have completed work in the Lavoie Group which has resulted in the synthesis of new square pyramidal complexes supported by the tert-butyl-substituted (ethenediylidene)tetraphenoxide “TPO” ligand system. Complexes 6, ... -
Measuring the Dynamics and Kinetics of OXA-58, a Class D Abeta-Lactamase from Acinetobacter Baumannii
(2015-12-16)OXA-58 is a β-lactamase enzyme that bacteria Acinetobacter baumannii employ as their chief defense mechanism against β-lactam antibiotic treatment. The catalytic activity of OXA-58 and its mutants was monitored as they ... -
Mass spectrometric investigation of the OH induced oxidation of isoprene using 0 2 + as a chemical ionization reagent
(2016-06-23)Isoprene (2-methyl-1,3-butadiene) is a dominant non-methane organic compound emitted into the atmosphere by vegetation, with an annual global emission rate of 500 Tg/yr. It represents almost 50% of all biogenic non-methane ... -
Exploring the Potential of Polyelectrolyte-Aptamer Films For Use in Optical and Electrochemical Sensing
(2016-09-20)Polyelectrolyte-aptamer films have emerged as versatile and easy-to-fabricate materials for applications ranging from cargo delivery to sensing. The films comprising charged polymers and DNA aptamers exhibit changes in the ... -
Part I: Application of Pd-Peppsi Complexes in Regioselective Cross-Coupling and Natural Product Total Synthesis; Part II: Room Temperature, Additive-Free Carbon-Sulfur Coupling Using Novel NHC-Pd Complexes
(2016-09-20)The first part of this research is focused on the development of an efficient method for the regioselective Suzuki-Miyaura cross-coupling of allylboronic acid pinacol ester derivatives with aryl and heteroaryl halides using ... -
Method Development For Concentration Measurements of SVOCs and Analysis of Ambient Samples
(2016-09-20)Semi-volatile organic compounds (SVOCs) comprise a wide range of toxic pollutants in the atmosphere. Phenols, polycyclic aromatic hydrocarbons (PAHs) and n-alkanes are specific examples of SVOCs that are the focus of this ... -
Front-End Methods For Enhancing the Analytical Power of Mass Spectrometry
(2016-09-20)The analytical power and versatility of mass spectrometry can be enhanced by adding front-end devices, which provide additional functionality before, during or immediately after ElectroSpray Ionization (ESI). Such devices ... -
Part I: Mechanistic Insight in Alkyl-Alkyl and Aryl-Aryl Negishi Cross-Coupling Part II: Large Scale Synthesis of NHC Precursors: 2,6-DI(3-Pentyl) Aniline and 2,6-DI (4-Heptyl) Aniline
(2016-09-20)Part I: An efficient method for alkyl-alkyl Negishi cross-coupling reaction of unactivated primary alkyl halides with higher-order zincate species (synthesized from dialkylzinc and a non-coordinating halide salt in situ) ... -
Measurement of Atmospheric NOy Species Using Active and Lunar DOAS in an Urban and Forested Region
(2016-09-20)The study of NOy serves as an important undertaking in the understanding of both night and daytime atmospheric processes. Two separate datasets were collected over the course of this research using Differential Optical ... -
Probing Charge Generation in 3D Photonic Poly(3-hexylthiophene)/Titanium Dioxide Nanocomposites for Bulk Heterojunction Solar Cells
(2016-09-20)Organic photovoltaics (OPVs) are attractive for their inexpensiveness, large-scale fabrication methods, flexibility and semi-transparency. OPVs have lower efficiencies than conventional inorganic semiconductor-based solar ... -
Palladium Mediated Synthesis of Substituted Phenols From Acyclic Ketones
(2016-09-20)The direct functionalization of phenols at the ortho and para position is generally facilitated by the electron-donating nature of the hydroxyl group. Accessing meta substituted phenols, on the other hand, often requires ... -
Nanostructured Mixed Transition Metal Spinel Oxide as Efficient Electrocatalysts
(2016-09-20)CuxCo3-xO4 films with x values ranging from 0 to 1 have prepared in order to optimize their electrocatalytic properties for the oxygen evolution reaction (OER). Two methods have been used for the preparation of CuxCo3-xO4, ... -
The Cocaine-Binding Aptamer: A Thermodynamic and Structural Overview of Specific and Non-Specific Binding Interactions
(2016-09-20)Isothermal Titration Calorimetry (ITC) studies were conducted wherein variances in the heat capacity of binding (Cp) among variants of the cocaine-binding aptamer were suggestive of two distinct binding mechanisms. Aptamer ... -
Surface and Interfacial Approaches for the Characterization of Biomolecular Interactions and to Optimize Desi-MS Performance
(2016-11-25)This work involves the surface and interfacial characterization of biomolecular interactions by atomic force microscopy and optimization of desorption electrospray ionization mass spectrometry. In the first part (part I), ... -
Examining the Effect of Poly (Ethylene glycol) and Non-Specific Insulin Binding on the Phase Behaviour of PEGylated Phosphocholine Membrane Models
(2016-11-25)Inclusion of synthetic poly-(ethylene glycol) (PEG)-grafted phospholipids into self-assembled phospholipid matrices is an exceptional method to engineering optimized bio-non-fouling membrane mimetic surfaces. The success ...