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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
PGC-1α is a transcriptional co-activator well established as a potent regulator of oxidative metabolism in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. ...
AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
There are multiple copies of mtDNA per cell and each mtDNA molecule contains the information to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated ...