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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
(2015-08-28)
PGC-1α is a transcriptional co-activator well established as a potent regulator of oxidative metabolism in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. ...
AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
(2014-07-09)
There are multiple copies of mtDNA per cell and each mtDNA molecule contains the information to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated ...