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The Role of Autophagy in the Maintenance of Mitochondrial Quality and Adaptations to Contractile Activity
(2015-08-28)
Autophagy is a critical survival mechanism facilitating protein turnover and pathogen defense in post-mitotic cells. More recently, mitophagy has been identified for the selective recognition and targeting of mitochondria ...
AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
(2014-07-09)
There are multiple copies of mtDNA per cell and each mtDNA molecule contains the information to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated ...